Histology and histopathology Vol. 1, nº 1 (1986)

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https://hdl.handle.net/10201/17679

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Oxygen toxicity in the infant rhesus monkey lung. Light microscopic and ultrastructural studies
(Murcia : F. Hernández, 1986) Ainsworthl, Dorothy M.; Keithl, lngegerd; Lobas, Jeffrey G.; Farrel, Philip M.; Eicker, W.
Eight monkeys were anesthetized with ketamine hydrochloride and positive pressure ventilated with >95% oxygen (tests) or room air (controls) for 24 hours. Two test monkeys and one control were treated with E. col; endotoxin (500 pg/kg) 1V at the start of the study and after 12 hours. Histopathological changes in the lung parenchyma were evaluated using light and electron microscopy. Interstitial edema was detected as early as 24 hours after the onset of hyperoxia but there was no significant increase in the alveolar-capillary distance (blood-air barrier). Morphologic signs of oxygen toxicity further included swelling and disruption of vascular endothelium, and swelling of alveolar Type I1 pneumocytes. There was no difference in the number of macrophages per high power field between the four groups but significant differences were observed in the number of neuroepithelial bodies (NEBs) per cmL and mast cells per high power field at the light microscopic level. Treatment with endotoxin did not protect against oxygen toxicity and was associated with an exacerbation of the morphological alterations in the lung parenchyma and swelling of alveolar Type 1 pneumocytes.
Open Access
Postnatal development of dendritic reticulum cells and their immune complex trapping ability.
(Murcia : F. Hernández, 1986) Yukata Imai; Michi Dobashi; Kazuo Terashima
The postnatal development of dendritic reticulum cells in the rat popliteal lymph nodes was electron microscopically investigated in relation to the appearance of immune complex trapping capacity. The popliteal lymph nodes of neonatal rat consisted of loosely arranged fibroblastic reticulum cells. In the following stage, the ueripheral cortex and paracortex became distinguishable. The former was made up of an accumulation of small lymphocytes, scattered within a framework of reticulum cells. On te 28 th day, the first primary follicle appeared in the peripheral cortex. Simultaneously the immune complex could be trapped on the cytoplasmic membrane of reticulum cells, which were located in the central portion of the primary follicles. The early image of germina1 centers appeared corresponding to immune complex trapping areas. In the well-developed secondary follicles, the immune complex trapping cells were mainly localized in the cap area. Their cytoplasmic membranes formed the dendritic processes, on which the distinct ability of trapping of the immune complex was recognized. It was dernonstrated that the fibroblastic reticulum cells, forming the stromaof lymph nodes, were transformed into the typicai dendritic reticulum cells with labyrinth structures in the cap area. Desmosomal junctions were often found, not only between the dendritic reticulum cells themselves, but aiso between the dendritic reticulum cells and lymphocytes. We suggest that the desmosomal junctions play a role as the channel for a transmission of immunological information.
Open Access
Primary malignant fibrous histiocytoma of the breast.
(Murcia : F. Hernández, 1986) Sigurd, Lunde; Nesland, Jahn M.; Holm, Ruth; Johannessen, Jan Vicents
Clinical, light microscopic, electron microscopic and immunocytochemical features of 4 cases (3 women and 1 man) of primary malignant fibrous histiocytoma (MFH) of the breast are presented. The literature is reviewed and the diagnosis and treatment discussed. The good outcome is stressed and local excisioo or simple mastectomy recommended as appropriate treatment .
Open Access
Morphologic and immunoelectronmicroscopic identification of human T cell lymphotropic virus type III (HTLV-III).
(Murcia : F. Hernández, 1986) Tirnár, J.; Nagy, K.; Lapis, K.
The AIDS associated HTLV-111 virus infected H9 cells were extensively studied using light, scanning and transmission electronmicroscopy. It was demonstrated that the morphological features of HTLV-111 are different from the C-type particles and are similar to those of lentiviridae. For immunological identification high titer pre-AIDS patient sera served as the anti-HTLV-111 envelope antibody source. The immunoelectronmicroscopic method was able to identify the viral envelope antigen on the surface of infected cells and in certain areas of the viral envelope. This is the first application of immunoelectronmicroscopy for the identification of the HTLV-111 virus
Open Access
Encephalopathy with astrocitic residual bodies. Report of a case and rewiev of the literature
(Murcia : F. Hernández, 1986) Figols, J.; Cervós-Navarro, J.; Wolman, M.
Biopsy and autopsy findings in a girl who died at 7% months after having suffered from progressive axial hypotonia, myoclonus, EEG changes and retarded psychomotor development. Inclusions consisting of lamellar profiles, situated in membrane-bound cytosomes were found mainly in astrocytes, but also in neurones and in axons of peripheral nerves. Lipofuscin bodies were also increased in number. The patient belongs in the same category as cases studied by Towfighi et al. (1975) and Martin et al. (1977). Etiology and pathogenesis of this syndrome remain unknown. It is suggested, however, that the pathological changes observed might have been caused by the administration soon after birth of anti-epileptic dmgs (diphenylhydantoin, clonazepam and nitrazepan).

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