Publication: Postnatal development of dendritic reticulum cells and their immune complex trapping ability.
Authors
Yukata Imai ; Michi Dobashi ; Kazuo Terashima
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The postnatal development of dendritic
reticulum cells in the rat popliteal lymph nodes was
electron microscopically investigated in relation to
the appearance of immune complex trapping capacity.
The popliteal lymph nodes of neonatal rat consisted of
loosely arranged fibroblastic reticulum cells. In the
following stage, the ueripheral cortex and paracortex
became distinguishable. The former was made up of an
accumulation of small lymphocytes, scattered within a
framework of reticulum cells. On te 28 th day, the first
primary follicle appeared in the peripheral cortex.
Simultaneously the immune complex could be trapped on
the cytoplasmic membrane of reticulum cells, which were
located in the central portion of the primary follicles. The
early image of germina1 centers appeared corresponding
to immune complex trapping areas. In the well-developed
secondary follicles, the immune complex trapping cells
were mainly localized in the cap area. Their cytoplasmic
membranes formed the dendritic processes, on which
the distinct ability of trapping of the immune complex was
recognized. It was dernonstrated that the fibroblastic
reticulum cells, forming the stromaof lymph nodes, were
transformed into the typicai dendritic reticulum cells with
labyrinth structures in the cap area.
Desmosomal junctions were often found, not only
between the dendritic reticulum cells themselves, but
aiso between the dendritic reticulum cells and lymphocytes.
We suggest that the desmosomal junctions play a role as
the channel for a transmission of immunological
information.
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