Publication: Oxygen toxicity in the infant rhesus monkey lung. Light microscopic and ultrastructural studies
Loading...
Date
1986
Authors
Ainsworthl, Dorothy M. ; Keithl, lngegerd ; Lobas, Jeffrey G. ; Farrel, Philip M. ; Eicker, W.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Eight monkeys were anesthetized with
ketamine hydrochloride and positive pressure ventilated
with >95% oxygen (tests) or room air (controls)
for 24 hours. Two test monkeys and one control were
treated with E. col; endotoxin (500 pg/kg) 1V at the start
of the study and after 12 hours. Histopathological changes
in the lung parenchyma were evaluated using light and
electron microscopy. Interstitial edema was detected as
early as 24 hours after the onset of hyperoxia but there
was no significant increase in the alveolar-capillary
distance (blood-air barrier). Morphologic signs of oxygen
toxicity further included swelling and disruption of
vascular endothelium, and swelling of alveolar Type I1
pneumocytes. There was no difference in the number of
macrophages per high power field between the four groups
but significant differences were observed in the number
of neuroepithelial bodies (NEBs) per cmL and mast cells
per high power field at the light microscopic level.
Treatment with endotoxin did not protect against oxygen
toxicity and was associated with an exacerbation of the
morphological alterations in the lung parenchyma and
swelling of alveolar Type 1 pneumocytes.
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.