Publication: Encephalopathy with astrocitic residual bodies. Report of a case and rewiev of the literature
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Date
1986
Authors
Figols, J. ; Cervós-Navarro, J. ; Wolman, M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Biopsy and autopsy findings in a girl who died
at 7% months after having suffered from progressive
axial hypotonia, myoclonus, EEG changes and retarded
psychomotor development. Inclusions consisting of
lamellar profiles, situated in membrane-bound cytosomes
were found mainly in astrocytes, but also in neurones
and in axons of peripheral nerves. Lipofuscin bodies
were also increased in number.
The patient belongs in the same category as cases
studied by Towfighi et al. (1975) and Martin et
al. (1977). Etiology and pathogenesis of this syndrome
remain unknown. It is suggested, however, that
the pathological changes observed might have been
caused by the administration soon after birth of
anti-epileptic dmgs (diphenylhydantoin, clonazepam
and nitrazepan).
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