Publication: Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats
Authors
Paredes, María Dolores ; Romecín, Paola ; Atucha, Noemí. M. ; O'Valle, Francisco ; Castillo, Julián ; Ortiz, M. Clara ; García-Estañ, Joaquín
item.page.secondaryauthor
item.page.director
Publisher
MDPI
publication.page.editor
publication.page.department
Description
© 2018. The authors.
This document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/
This document is the published version of a published work that appeared in final form in
Nutrients
Abstract
Background: we have evaluated the antihypertensive effect of several flavonoid extracts
in a rat model of arterial hypertension caused by chronic administration (6 weeks) of the nitric
oxide synthesis inhibitor, L-NAME. Methods: Sprague Dawley rats received L-NAME alone or
L-NAME plus flavonoid-rich vegetal extracts (Lemon, Grapefruit + Bitter Orange, and Cocoa) or
purified flavonoids (Apigenin and Diosmin) for 6 weeks. Results: L-NAME treatment resulted in a
marked elevation of blood pressure, and treatment with Apigenin, Lemon Extract, and Grapefruit +
Bitter Orange extracts significantly reduced the elevated blood pressure of these animals. Apigenin
and some of these flavonoids also ameliorated nitric oxide-dependent and -independent aortic
vasodilation and elevated nitrite urinary excretion. End-organ abnormalities such as cardiac infarcts,
hyaline arteriopathy and fibrinoid necrosis in coronary arteries and aorta were improved by these
treatments, reducing the end-organ vascular damage. Conclusions: the flavonoids included in this
study, specially apigenin, may be used as functional food ingredients with potential therapeutic
benefit in arterial hypertension
publication.page.subject
Citation
item.page.embargo
Collections
Ir a Estadísticas
Este ítem está sujeto a una licencia Creative Commons. Licencia Creative Commons