Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats

Paredes, María Dolores; Romecín, Paola; Atucha, Noemí. M.; O'Valle, Francisco; Castillo, Julián; Ortiz, M. Clara; García-Estañ, Joaquín

Publication:
Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats

dc.contributor.author	Paredes, María Dolores
dc.contributor.author	Romecín, Paola
dc.contributor.author	Atucha, Noemí. M.
dc.contributor.author	O'Valle, Francisco
dc.contributor.author	Castillo, Julián
dc.contributor.author	Ortiz, M. Clara
dc.contributor.author	García-Estañ, Joaquín
dc.contributor.department	Fisiología
dc.date.accessioned	2024-01-23T13:16:40Z
dc.date.available	2024-01-23T13:16:40Z
dc.date.issued	2018-04-13
dc.description	© 2018. The authors. This document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/ This document is the published version of a published work that appeared in final form in Nutrients	es
dc.description.abstract	Background: we have evaluated the antihypertensive effect of several flavonoid extracts in a rat model of arterial hypertension caused by chronic administration (6 weeks) of the nitric oxide synthesis inhibitor, L-NAME. Methods: Sprague Dawley rats received L-NAME alone or L-NAME plus flavonoid-rich vegetal extracts (Lemon, Grapefruit + Bitter Orange, and Cocoa) or purified flavonoids (Apigenin and Diosmin) for 6 weeks. Results: L-NAME treatment resulted in a marked elevation of blood pressure, and treatment with Apigenin, Lemon Extract, and Grapefruit + Bitter Orange extracts significantly reduced the elevated blood pressure of these animals. Apigenin and some of these flavonoids also ameliorated nitric oxide-dependent and -independent aortic vasodilation and elevated nitrite urinary excretion. End-organ abnormalities such as cardiac infarcts, hyaline arteriopathy and fibrinoid necrosis in coronary arteries and aorta were improved by these treatments, reducing the end-organ vascular damage. Conclusions: the flavonoids included in this study, specially apigenin, may be used as functional food ingredients with potential therapeutic benefit in arterial hypertension	es
dc.format	application/pdf	es
dc.format.extent	15	es
dc.identifier.citation	Nutrients 2018, 10, 484;
dc.identifier.doi	https://doi.org/10.3390/nu10040484
dc.identifier.issn	Electronic: 2072-6643
dc.identifier.uri	http://hdl.handle.net/10201/137622
dc.language	eng	es
dc.publisher	MDPI	es
dc.relation	: This report was supported by a grant from the National Spanish R&D Program CENIT of the Spanish Ministry of Science and Technology denominated “Industrial research diets and food with specific features for the elderly”, CEN-20091006; Acronym: SENIFOOD. We have not received funds for covering the costs to publish in open access	es
dc.relation.publisherversion	https://www.mdpi.com/2072-6643/10/4/484	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Atribución 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.subject	Flavonoides	es
dc.subject	Hipertensión arterial	es
dc.subject	Óxido nítrico	es
dc.subject	Flavonoids	es
dc.subject	Nitric oxide	es
dc.subject	Heart; kidney	es
dc.subject	Sodium balance	es
dc.subject	Phenylephrine	es
dc.subject	Acetylcholine	es
dc.subject.other	CDU::6 - Ciencias aplicadas::61 - Medicina::612 - Fisiología	es
dc.title	Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es