Publication: Cadmium- and lead-induced apoptosis in mallard erythrocytes (Anas platyrhynchos)
Authors
Romero García, Diego ; Hernández-García, A. ; Tagliati, C. A. ; Martínez-López, E. ; García Fernández, Antonio Juan
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Publisher
Elsevier
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DOI
https://doi.org/10.1016/j.ecoenv.2008.05.004
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info:eu-repo/semantics/article
Description
©2008 Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
This document is the Published version of a Published Work that appeared in final form in Ecotoxicology and Environmental Safety. To access the final edited and published work see https://doi.org/10.1016/j.ecoenv.2008.05.004
Abstract
Cadmium, lead and cadmium–lead (1:10) induced apoptosis were studied using mallard blood cells. The allowable range in concentrations were: 0.01–0.5, 0.1–5.0, and 0.01:0.10–0.50:5.00 mM, for cadmium, lead and cadmium–lead, respectively. The lowest EC50 achieved was for cadmium (0.2270.04 mM). Two doses from each treatment group were chosen to study apoptosis and the presence of metals in cells. The percentage of apoptotic cells increased as the concentration of metals increased. The percentage of cells with intracellular metals was high for both exposure levels and the quantity of intracellular metal was greater for exposure to high concentrations. Morphological alterations for all types of exposure were related to the diverse range of effects that these metals have on membranes. We suggest that the decrease in the number of erythrocytes observed in specimens suffering from lead and cadmium poisoning is related to the induction of apoptosis.
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Citation
Ecotoxicology and Environmental Safety, Vol. 72, N. 1, 2009, 37– 44
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