DigitalUM :: Browsing by browse.metadata.contributordepartment "Ciencias Sociosanitarias"

Browsing by browse.metadata.contributordepartment "Ciencias Sociosanitarias"

Now showing 1 - 20 of 296

Open Access
A Bayesian joinpoint regression model with an unknown number of break-points
(Institute of Mathematical Statistics, 2011-09) Martínez-Beneito, M.A.; García-Donato, G.; Salmerón Martínez, Diego; Ciencias Sociosanitarias
Joinpoint regression is used to determine the number of segments needed to adequately explain the relationship between two variables. This methodology can be widely applied to real problems, but we focus on epidemiological data, the main goal being to uncover changes in the mortality time trend of a specific disease under study. Traditionally, Joinpoint regression problems have paid little or no attention to the quantification of uncertainty in the estimation of the number of change-points. In this context, we found a satisfactory way to handle the problem in the Bayesian methodology. Nevertheless, this novel approach involves significant difficulties (both theoretical and practical) since it implicitly entails a model selection (or testing) problem. In this study we face these challenges through (i) a novel reparameterization of the model, (ii) a conscientious definition of the prior distributions used and (iii) an encompassing approach which allows the use of MCMC simulation-based techniques to derive the results. The resulting methodology is flexible enough to make it possible to consider mortality counts (for epidemiological applications) as Poisson variables. The methodology is applied to the study of annual breast cancer mortality during the period 1980–2007 in Castellón, a province in Spain.
Embargo
A comparison of BGM and LLC-PK1 cells for the evaluation of nephrotoxicity
(Taylor and Francis Group, 2011-09-22) Tagliati, Carlos A.; Dutra, Elisabete C.R.; Hernández-García, Alejandro; García Fernández, Antonio Juan; Martínez López, Emma; Romero García, Diego; Ciencias Sociosanitarias
Nephrotoxicity is one of the most frequent effects observed after the use of medicine. Such situations have been tardily discovered because of existing methods to determine toxicity. The validation of sensitive, alternative methods for the early identification of toxic effects is as important as restrictions on the use of animals. In this light, the present study evaluated the effects of gentamicin on BGM and LLC-PK1 cells, using MTT and Neutral Red (NR). Although the LLC-PK1 cell line is used for toxicological studies, the BGM cell line is relatively new for this purpose. MTT (BGM: EC50=6.29mM; LLC-PK1: EC50=8.01mM) was found to be more sensitive than NR (EC50 was greater than 10mM for both cells). By using MTT, both cells demonstrated the involvement of mitochondria in a manner that was dose dependent, with an apoptotic process occurring at the concentrations of 1 and 3mM and necrosis at concentrations above 4mM. It could, therefore, be concluded that 1) BGM appears to be useful in the study of the mechanism of nephrotoxicity caused by gentamicin and 2) because of its sensitivity to MTT, in addition to its ease of manipulation, it is believed that the BGM cell line can also be used as an alternative method to evaluate nephrotoxicity.
Restricted
A critical review about neurotoxic effects in marine mammals of mercury and other trace elements
(Elsevier, 2020-05) López Berenguer, Gabriel; Martínez López, Emma; Peñalver García, José; Ciencias Sociosanitarias
Marine mammals are more exposed to mercury (Hg) than any others animals in the world. As many trace elements, Hg it is able to impair the brain function, which could be a cause of population decline. Nevertheless, these issues have been scarcely studied because of the technical and ethical difficulties. We conducted a systematic review about marine mammals’ brain exposition to Hg and other trace elements, and their neurotoxic effects. Information was scarce and the lack of standardization of nomenclature of brain structures, sample collecting and results presentation made it difficult to obtain conclusions. Hg was the most studied metal and toothed whales the most studied group. Despite being its target organ, brain accumulates lesser concentrations of Hg than other tissues as liver. We found a significant positive correlation between both organs’ burden (rho = 0.956 for cetaceans; rho = 0.756 for pinnipeds). Reported Hg values in brain of cetaceans (median 3.00 ppm ww) surpassed by one or two orders of magnitude those values found in other species as pinnipeds (median 0.33 ppm ww) or polar bears (median 0.07 ppm ww). Such values exceeded neurotoxicity thresholds. Although marine mammals ingest mostly the organic and more toxic form MeHg, different fractions of inorganic mercury can appear in brain, which could suggest some detoxification mechanisms. Other suggested mechanisms include Se–Hg interaction and liver sequestration. Although other elements are subjected to a rigid homeostatic control, appear in low concentrations or do not exert an important neurotoxic effect, they should be more studied to elucidate their neurotoxicity potential.
Restricted
A Novel Founder Mutation in MYBPC3: Phenotypic Comparison With the Most Prevalent MYBPC3 Mutation in Spain.
(Elsevier, 2016-10-28) Saura, Daniel; García Molina Sáez, Esperanza; González Carrillo, Josefa; Polo, Luis; Pérez Sánchez, Inmaculada; Olmo, María Carmen; Oliva Sandoval, María José; Barriales Villa, Roberto; Carbonell, Pablo; Pascual Figal, Domingo A.; Gimeno, Juan Ramón; Sabater Molina, María; Ciencias Sociosanitarias
Introducción y objetivos: Las mutaciones en MYBPC3 son causa de miocardiopatía hipertrófica (MCH). A pesar de que la mayorı´a de ellas producen una proteína truncada, la gravedad del fenotipo es diversa. Se describe el fenotipo clínico de una nueva mutación en MYBPC3, p.Pro108Alafs*9, presente en 13 familias del sur de España, y se compara con la mutación de MYBPC3 con mayor prevalencia en dicha región (c.2308 + 1 G > A). Métodos: Se estudió a 107 familiares de 13 casos índice que tenían diagnóstico de MCH y portaban la mutación p.Pro108Alafs*9. Se realizó un anélisis del árbol genealógico, junto con una evaluación clínica y determinación del genotipo. Resultados: Se identificó en total a 54 portadores de la mutación p.Pro108Alafs*9, de los que 39 tenían MCH. Hubo 5 casos de muerte súbita en las 13 familias. La penetrancia de la enfermedad aumentaba a medida que se incrementaba la edad, y los pacientes con MCH fueron con más frecuencia varones, y estos contrajeron la enfermedad más precozmente que las mujeres. El fenotipo fue similar en la p.Pro108Alafs*9 y la c.2308 + 1 G > A, pero se observaron diferencias en varios factores de riesgo y en la supervivencia. Hubo tendencia a mayor masa ventricular izquierda en la p.Pro108Alafs*9 que en la c.2308 + 1G > A. La resonancia magnética cardiaca reveló una extensión y un patrón de fibrosis similares en ambas. Conclusiones: La mutación p.Pro108Alafs*9 se asoció a MCH, alta penetrancia y aparición de la enfermedad a mediana edad.
Open Access
Accuracy of anogenital distance and anti-Müllerian hormone in the diagnosis of endometriosis without surgery
(Wiley, 2019) Jiménez-Velázquez, Raquel; Carmona-Barnosi, Ana; Corbalán-Biyang, Shiana; Hernández-Peñalver, Ana I.; Adoamnei, Evdochia; Mendiola Olivares, Jaime; Torres Cantero, Alberto Manuel; Cánovas López, Laura; Nieto Díaz, Anibal; Prieto Sánchez, María Teresa; Sánchez Ferrer, María Luisa; Cirugía, Pediatría y Obstetricia y Ginecología; Ciencias Sociosanitarias
Objective: To assess the predictive ability of a combination of anogenital distance (AGD) and anti-Müllerian hormone (AMH) to diagnosis the presence of endometriosis without surgery. Methods: The present study included women diagnosed with endometriosis and a control group who attended the "Virgen de la Arrixaca" University Hospital, Murcia, Spain, between September 1, 2014, and May 31, 2015. Serum concentrations of AMH were measured, and two AGD measurements were obtained: from the anterior clitoral surface to the upper verge of the anus (AGDAC ), and from the posterior fourchette to the upper verge of the anus (AGDAF ). Data were assessed by receiver operator characteristic (ROC) curves. Results: Women in the endometriosis group (n=57) had significantly shorter AGDAF (22.8 ± 4.6 vs 27.2 ± 5.7 mm; P<0.001) and lower AMH (2.2 ± 2.5 vs 3.3 ± 1.9 ng/mL; P<0.003) compared with the control group (n=93). Women with serum AMH below the clinical cut-off (1 ng/mL) were 17.40-times more likely to have endometriosis (95% confidence interval [CI] 5.64-53.82). The area under the ROC curve of combined AMH and AGDAF was 0.77 (95% CI 0.70-0.85). Conclusion: The model for predicting endometriosis on the basis of AMH and AGD could be useful for clinicians and epidemiologists to improve diagnosis and prognosis of this condition.
Restricted
Activating KIRs on Educated NK Cells Support Downregulation of CD226 and Inefficient Tumor Immunosurveillance
(American Association for Cancer Research, 2019-08-01) Guillamón, Concepción F.; Martínez Sánchez, María V.; Campillo, José A.; Server Pastor, Gerardo; Martínez García, Jerónimo; Martínez Escribano, Jorge; Torroba, Amparo; Ferri, Belén; Abellán, Daniel J.; López Álvarez, María R.; Moya Quiles, María R.; Muro, Manuel; Minguela, Alfredo; Gimeno Arias, Lourdes; Legaz Pérez, Isabel; Ciencias Sociosanitarias
Therapies using NK cells (NKc) expanded/activated ex vivo or stimulated in vivo with new immunostimulatory agents offer alternative opportunities for patients with recurrent/refractory tumors, but relevant biomarkers to guide the selection of patients are required for optimum results. Overall survival of 249 solid cancer patients was evaluated in relation to the genetics and/or the expression on peripheral blood NKcs of inhibitory and activating killer-cell immunoglobulin-like receptors (iKIR and aKIR, respectively), HLA class I ligands, CD226 (also known as DNAM-1), and NKG2A. Compared with patients with higher expression, patients with low expression of CD226 on total NKcs showed shorter mean overall survival (60.7 vs. 98.0 months, P < 0.001), which was further reduced in presence of telomeric aKIRs (KIR2DS1-DS5 and/or KIR3DS1, 31.6 vs. 96.8 months, P < 0.001). KIR2DL2/S2+, KIR3DL1+, KIR2DL1+, and KIR2DL3+ NKc subsets in the presence of their cognate ligands primarily contributed to shortening patients’ overall survival by increasing the sensitivity to CD226 downmodulation in aKIR-rich telomeric genotypes. In patients with high tumor burden who died during the follow-up period, aKIR-rich telomeric genotypes were associated with: (i) specific downmodulation of CD226 on educated NKcs but not on CD8+ T cells or uneducated NKcs, (ii) lower expression of CD226 and higher expression of NKG2A on aKIR+ NKcs, and (iii) lower numbers of total CD56dim NKcs. The reduced expression of CD226 on NKcs with aKIR-rich genotypes may be a biomarker indicative of NKc hyporesponsiveness in patients that could benefit from new NKc immune-stimulatory therapies.
Open Access
Active monitoring of long-eared owl (Asio otus) nestlings reveals widespread exposure to anticoagulant rodenticides across different agricultural landscapes
(Elsevier, 2024-03-25) Zamora Marín, José Manuel; León Ortega, Mario; Díaz García, Sarah; Tecles, Fernando; Fenoll, José; Cava, Juana; Calvo, José Francisco,; García Fernández, Antonio Juan; Gómez Ramírez, Pilar; Spadetto, Livia; Ciencias Sociosanitarias
The widespread use of anticoagulant rodenticides (ARs) poses a worldwide threat to farmland wildlife. These compounds accumulate in tissues of both target and non-target species, potentially endangering both direct consumers and their predators. However, investigations on ARs in blood of free-ranging predatory birds are rare. Here, the long-eared owl (Asio otus) has been used as a model predator to assess AR exposure in different agricultural landscapes from a Mediterranean semiarid region. A total of 69 owlets from 38 nests were blood-sampled over 2021 and 2022, aiming to detect AR residues and explore factors that determine their exposure, such as land uses. In addition, prothrombin time (PT) test was conducted to assess potential effects of AR contamination. Overall, nearly all the samples (98.6 %) tested positive for at least one compound and multiple ARs were found in most of the individuals (82.6 %). Among the ARs detected, flocoumafen was the most common compound (88.4 % of the samples). AR total concentration (Sigma ARs) in blood ranged from 0.06 to 34.18 ng mL(-1), detecting the highest levels in the most intensively cultivated area. The analysis of owl pellets from 19 breeding territories showed relevant among-site differences in the contribution of rodents and birds into the diet of long-eared owls, supporting its high dietary plasticity and indicating AR presence at multiple trophic levels. Moreover, a positive and significant correlation was found between Sigma ARs and PT (Rho = 0.547, p < 0.001), which demonstrates the direct effect of ARs on free-living nestlings. Our results provide a preliminary overview of AR exposure in a little-studied owl species inhabiting agricultural and rural landscapes. Despite the low detected levels, these findings indicate widespread exposure -often to multiple compounds- from early life stages, which raises concern and draws attention to an ongoing and unresolved contamination issue.
Open Access
Acute phase protein concentrations in retired racing Greyhounds
(Wiley, 2009-06) Guillermo Couto, C.; Cerón Madrigal, José Joaquín; Martínez-Subiela, Silvi; Lazbik, M. Cristina; Parra Muñoz, María Dolores; Ciencias Sociosanitarias
Background: Retired racing Greyhounds are popular as pets. Greyhounds have several differences in physiological values compared with other breeds, including lower serum a- and b-globulin concentrations. We hypothesized that lower acute phase protein (APP) concentrations could contribute to lower a- and b-globulin concentrations in this breed. Objectives: The purpose of this study was to compare serum concentrations of several APPs in Greyhounds with those of other dog breeds. Methods: We measured the serum concentrations of C-reactive protein (CRP), haptoglobin (Hp), acid-soluble glycoprotein (ASG), ceruloplasmin (CP), and serum amyloid A (SAA) in 15 clinically healthy retired racing Greyhounds and 11 age- and gender-matched healthy nonGreyhound controls using previously validated methods. Results were compared by Student’s t-tests. Results: The concentration of Hp by both colorimetric and immunoturbidimetric methods was significantly lower in Greyhounds than in nonGreyhound dogs (P =.0009 and .019, respectively). The concentration of ASG was also significantly (P =.007) lower in Greyhounds, but CRP and CP concentrations were not significantly different between groups. SAA concentration was below the detection limit of the method in all dogs. Conclusions: The low serum concentrations of Hp and ASG should be taken into consideration when interpreting APP results in Greyhounds. Because both Hp and some ASG migrate in the a-globulin fraction, these results may explain the low a-globulin concentrations in Greyhounds.
Open Access
Age and education as factors associated with medication literacy: a community pharmacy perspective
(BMC, 2020-11-25) Legaz Pérez, Isabel; Osuna Carrillo-Albornoz, Eduardo Javier; Pérez Cárceles, María Dolores; Plaza Zamora, Francisco Javier; Ciencias Sociosanitarias
Background: Aging implies a higher prevalence of chronic pathologies and a corresponding increase in medication. The correct adherence and use of the medication are prerequisites for reducing risks of disease progression, comorbidity, and mortality. Medication literacy (ML) is the specific ability to safely access and understand the information available concerning medication, and to act accordingly. Currently, there are few specific instruments that ascertain the extent of ML in the general population. The aim of this work was to analyse ML in a large cohort of pharmacy customers. Methods: A total of 400 community pharmacy clients were analyzed to assess the level of ML (documental and numeracy) through the validated MedLitRxSE tool. Results: The results showed that out of a total of 400 community pharmacy clients only 136 (34%) had an adequate degree of ML, while the rest of the clients (n = 264; 66%) were adjudged not to have this ability. Statistically significant differences were found between the different age groups in terms of ML (P < 0.001; OR = 0.312; 95% CI: 0.195–0.499), the 51–65 and >65-year age groups having a lower frequency of adequate ML (23.5 and 7.1%, respectively) than the rest of the age groups. A statistically significant increase in adequate ML was observed as the academic level of the clients increased (P < 0.001; OR = 15.403; 95% CI: 8.109–29.257). Multivariate logistic regression confirmed the influence of both variables on ML. Conclusions: An inadequate ML level was found in community pharmacy clients over the age of 51, and also in those with primary or non-formal studies. Our data add to our knowledge about ML, and should pharmacists and other health professionals to adopt new strategies to prevent, or at least reduce, errors in taking medicines, thus avoiding the undesirable effects of any misuse.
Open Access
Aging and trace elements in human coronal tooth dentine
(Nature Research, 2020-06-19) Fernández Escudero, Ana C.; Prieto Bonete, Gemma; López Nicolás, Manuel; Maurandi López, Antonio; Legaz Pérez, Isabel; Pérez Cárceles, María Dolores; Ciencias Sociosanitarias
Teeth are a fundamental tool in forensic odontology for identification in a legal context of those individuals who cannot be identified visually or by other means. Dentine presents physiological exchanges of in trace elements after a period of mineralization and several factors can affect its concentration. The aim of this study was to investigate the concentration of 25 trace elements in the coronal dentine according to sex and type of tooth to determine their relationship with age. A total of 25 trace elements were analyzed in 150 human coronal dentine. Teeth were classified into three age groups, sex and tooth type. The trace elements were grouped as potentially toxic or essential. Inductively Coupled Plasma-Mass Spectrometry and Atomic Emission Spectroscopy were used. The toxic and essential elements were detected in the following order of concentration: Al > Pb > Sn > Li > As > Cd and Ca > P > Mg > Na > S > K > Sr > Zn > Ba > Fe > B > Ti > Mn > Cr > Ni > Cu > Co > Se > V. Our findings show an increase in the concentration of toxic (Pb, Li and Sn) and essential (B, Ba, K, Sr, S and Mg) elements in coronal dentin related to the age of the teeth, regardless of sex. The concentrations of Pb and K in dentin of molars and premolars are the elements that best relate their variations with age. In view of our results, the analysis of these trace elements in dentin in combination with other types of techniques could be established as an element to consider in age dating studies in different forensic situations.
Open Access
Alcohol-related diseases and liver metastasis: role of cell-free network communication
(Baishideng Publishing Group, 2022-08-14) Muro, Manuel; Collados Ros, Aurelia; Legaz Pérez, Isabel; Ciencias Sociosanitarias
Alcohol intake is a risk factor for cancer development and metastatic disease progression. Extracellular vesicle (EV)-mediated interorgan communication is assumed to be significant in boosting tumorigenic pathways and disease progression. Recent research indicates that exosomes have a variety of roles in the development of cancer during pathophysiological conditions. The involvement of EV signaling during cancer progression in the alcohol environment is unknown. Therefore, understanding communication networks and the role of EVs as biomarkers can contribute significantly to developing strategies to address the serious public health problems associated with alcohol consumption and cancer.
Open Access
All that glitters in cfDNA analysis is not gold or its utility is completely established due to graft damage: a critical review in the field of transplantation
(MDPI, 2023-06-06) Jiménez Coll, Víctor; El kaaoui El band, Jaouad; Llorente, Santiago; González López, Rosana; Fernández González, Marina; Martínez Banaclocha, Helios; Galián, José Antonio; Botella, Carmen; Moya Quiles, María Rosa; Minguela, Alfredo; Muro, Manuel; Legaz Pérez, Isabel; Ciencias Sociosanitarias
In kidney transplantation, a biopsy is currently the gold standard for monitoring the transplanted organ. However, this is far from an ideal screening method given its invasive nature and the discomfort it can cause the patient. Large-scale studies in renal transplantation show that approximately 1% of biopsies generate major complications, with a risk of macroscopic hematuria greater than 3.5%. It would not be until 2011 that a method to detect donor-derived cell-free DNA (dd-cfDNA) employing digital PCR was devised based on analyzing the differences in SNPs between the donor and recipient. In addition, since the initial validation studies were carried out at the specific moments in which rejection was suspected, there is still not a good understanding of how dd-cfDNA levels naturally evolve post-transplant. In addition, various factors, both in the recipient and the donor, can influence dd-cfDNA levels and cause increases in the levels of dd-cfDNA themselves without suspicion of rejection. All that glitters in this technology is not gold; therefore, in this article, we discuss the current state of clinical studies, the benefits, and disadvantages.
Restricted
Alterations in haemolymph proteome of Mytilus galloprovincialis mussel after an induced injury
(Elsevier, 2018-01-31) Franco-Martínez, Lorena; Martínez-Subiela, Silvia; Escribano, Damián; Schlosser, Sarah; Nöbauer, Katharina; Razzazi-Fazeli, Ebrahím; Cerón, José Joaquín Cerón; Tvarijonaviciute, Asta; Romero García, Diego; Ciencias Sociosanitarias
A proteomic and biochemical approach was performed to assess the effects of an induced muscle injury on the haemolymph of bivalve molluscs. For this purpose, Mytilus galloprovincialis were exposed to puncture of adductor muscle for three consecutive days, and their haemolymph proteome was then compared to healthy animals using 2-dimensional electrophoresis (2-DE) to identify proteins that differed significantly in abundance. Those proteins were then subjected to tandem mass spectrometry and 6 proteins, namely myosin, tropomyosin, CuZn super-oxide dismutase (SOD), triosephosphate isomerase, EP protein and small heat shock protein were identified. SOD and tropomyosin changes were verified by spectrophotometric measurements and western blotting, respectively. As some of the proteins identified are related to muscular damage and oxidative stress, other biomarkers associated with these processes that can be evaluated by automatic biochemical assays were measured including troponin, creatine kinase (CK), and aspartate aminotransferase (AST) for muscle damage, and SOD, trolox equivalent antioxidant capacity (TEAC) and esterase activity (EA) for oxidative stress. Significantly higher concentrations of troponin, CK, AST, and TEAC were observed in mussels after puncture, being also possible biomarkers of non-specific induced damage.
Restricted
An integrative perspective on ﬁsh health: environmental and anthropogenic pathways affecting ﬁsh stress
(Elsevier, 2023-08-03) Schull, Quentin; Beauvieux, Anaïs; Viblanc, Vincent A.; Metral, Luisa; Leclerc, Lina; Pernet, Fabrice; Quéré, Claudie; Derolez, Valérie; Munaron, Dominique; McKindsey, Christopher W.; Saraux, Claire; Bourjea, Jerôme; Romero García, Diego; Ciencias Sociosanitarias
Multifactorial studies assessing the cumulative effects of natural and anthropogenic stressors on individual stress response are crucial to understand how organisms and populations cope with environmental change. We tested direct and indirect causal pathways through which environmental stressors affect the stress response of wild gilthead seabream in Mediterranean costal lagoons using an integrative PLS-PM approach. We integrated in-formation on 10 environmental variables and 36 physiological variables into seven latent variables reﬂecting lagoons features and ﬁsh health. These variables concerned ﬁsh lipid reserves, somatic structure, inorganic contaminant loads, and individual trophic and stress response levels. This modelling approach allowed explaining 30 % of the variance within these 46 variables considered. More importantly, 54 % of ﬁsh stress response was explained by the dependent lagoon features, ﬁsh age, ﬁsh diet, ﬁsh reserve, ﬁsh structure and ﬁsh contaminant load latent variables included in our model. This integrative study sheds light on how individuals deal with contrasting environments and multiple ecological pressures.
Open Access
Análisis de biomarcadores
(2020-02-14) Gómez Ramírez, Pilar; Ciencias Sociosanitarias; Facultad de Medicina
Open Access
Análisis de la dispensación de medicamentos para el control de los principales factores de riesgo cardiovascular en la Región de Murcia: existen diferencias de género?
(2014) Sánchez, Fernando I.; Sánchez Martínez, Diego Pablo; Torres Cantero, Alberto Manuel; Guillén Pérez, José Jesús; Ciencias Sociosanitarias
Open Access
Análisis de situación la Región de Murcia. la salud de los murcianos, sus determinantes y la prevención de los problemas prioritarios
(2003) Aguinaga Ontoso, Enrique; Ciencias Sociosanitarias
Open Access
Análisis por conglomerados
(Universidad de Murcia. Facultad de Medicina, 2026) Timón Pèrez, Isabel María; Ciencias Sociosanitarias; Facultades de la UMU::Facultad de Medicina
Material docente orientado a la introducción y aplicación del análisis por conglomerados. Incluye fundamentos teóricos, descripción de métodos, criterios para la selección del número de clusters y ejemplos prácticos mediante SPSS. Dirigido a estudiantes de Ciencias de la Salud con enfoque aplicado al análisis de datos.
Open Access
Análisis toxicológico
(2020-02-14) Gómez Ramírez, Pilar; Ciencias Sociosanitarias; Facultad de Medicina
Open Access
Analysis of hepatitis C virus-positive organs in liver transplantation
(Baishideng Publishing Group, 2022-09-27) Muro, Manuel; Legaz Pérez, Isabel; Ciencias Sociosanitarias
The authors of this study note that in liver transplantation (LT), the survival rates of hepatitis C virus (HCV)-positive donors and HCV-negative receivers are comparable to those of HCV-negative donors and recipients. Direct-acting antiviral (DAA) therapies have nearly 100% effectiveness in treating HCV. Between 2006 and 2016, the percentages of HCV-positive patients on the waiting list and HCV-positive LT recipients fell by 8.2 percent and 7.6 percent, respectively. Records from April 1, 2014, in which the donor and receiver were both at least 18 years old and had a positive HCV status, were the only ones eligible for the study. The analysis for this study was restricted to the first transplant recorded for each patient using a data element that documented the number of prior transplants for each recipient, although some recipients appeared multiple times in the data set. HCV-positive recipients or people with fulminant hepatic failure were the main beneficiaries of primary biliary cirrhosis among HCV-positive donors. However, there is still a reticence to use HCV-positive donor organs in HCV recipients due to clinical and ethical considerations. Similar survival rates between HCV-positive donors and recipients and HCV-negative donors and receivers illustrate the efficacy of these DAA regimens.