Publication: Risk factors and primary prevention of congenital Chagas disease in a nonendemic country
Date
2012-10-24
Authors
Murcia, Laura ; Carrilero, Bartolomé ; Muñoz-Dávila, M. Jose ; Thomas, M. Carmen ; López, Manuel C. ; Segovia, Manuel
item.page.secondaryauthor
item.page.director
Publisher
Oxford University Press
publication.page.editor
publication.page.department
Description
© The Authors 2012.___ This document is the published version of a published work that appeared in final form in Clinical Infectious Diseases
___
To access the final edited and published work see:
https://doi.org/10.1093/cid/cis910
Abstract
Background. In this longitudinal cohort study we evaluated the congenital transmission of Chagas disease
(CD) in a nonendemic area. The aim of this work was to analyze the predictive value of a Trypanosoma cruzi–
positive polymerase chain reaction (PCR) result in pregnant women for the diagnosis of vertical transmission and
to evaluate the use of PCR as a tool for early detection of infection.
Methods. The offspring of 59 seropositive pregnant mothers were followed up. The parasitological status of
mothers was studied by PCR in a total of 64 pregnancies; 10 of these women had received treatment before
pregnancy. Sixty-five infants (including a pair of twins) were monitored at 0, 6, 9, and 12 months of age by PCR
and serology. In cases of congenital transmission, hemoculture and parasite lineage typing were performed.
Results. Nine infants had acquired CD congenitally. This represents a transmission rate of 13.8% among seropositive
mothers (9 infected newborns of 65 total live births). All infants were infected with T. cruzi discrete typing unit V
strain. A statistically significant correlation was found between T. cruzi vertical transmission and a positive PCR result
during pregnancy (31%; 9 infected newborns in 29 live births). No infected infants were detected among 10 mothers
who were treated before they became pregnant, compared with 16.4% (9 of 55 live births) among untreated mothers.
Conclusions. PCR is a useful tool for the detection of congenital CD, and the treatment of infected women of
childbearing age seems to be useful for preventing vertical transmission.
publication.page.subject
Citation
Clinical Infectious Diseases, Volume 56, Issue 4, 15 February 2013, Pages 496–50
item.page.embargo
01-ene-2999
Collections
Ir a Estadísticas
Sin licencia Creative Commons.