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Risk factors and primary prevention of congenital Chagas disease in a nonendemic country

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dc.contributor.authorMurcia, Laura
dc.contributor.authorCarrilero, Bartolomé
dc.contributor.authorMuñoz-Dávila, M. Jose
dc.contributor.authorThomas, M. Carmen
dc.contributor.authorLópez, Manuel C.
dc.contributor.authorSegovia, Manuel
dc.contributor.departmentGenética y Microbiología
dc.date.accessioned2025-09-18T10:18:45Z
dc.date.available2025-09-18T10:18:45Z
dc.date.issued2012-10-24
dc.description© The Authors 2012.___ This document is the published version of a published work that appeared in final form in Clinical Infectious Diseases ___ To access the final edited and published work see: https://doi.org/10.1093/cid/cis910
dc.description.abstractBackground. In this longitudinal cohort study we evaluated the congenital transmission of Chagas disease (CD) in a nonendemic area. The aim of this work was to analyze the predictive value of a Trypanosoma cruzi– positive polymerase chain reaction (PCR) result in pregnant women for the diagnosis of vertical transmission and to evaluate the use of PCR as a tool for early detection of infection. Methods. The offspring of 59 seropositive pregnant mothers were followed up. The parasitological status of mothers was studied by PCR in a total of 64 pregnancies; 10 of these women had received treatment before pregnancy. Sixty-five infants (including a pair of twins) were monitored at 0, 6, 9, and 12 months of age by PCR and serology. In cases of congenital transmission, hemoculture and parasite lineage typing were performed. Results. Nine infants had acquired CD congenitally. This represents a transmission rate of 13.8% among seropositive mothers (9 infected newborns of 65 total live births). All infants were infected with T. cruzi discrete typing unit V strain. A statistically significant correlation was found between T. cruzi vertical transmission and a positive PCR result during pregnancy (31%; 9 infected newborns in 29 live births). No infected infants were detected among 10 mothers who were treated before they became pregnant, compared with 16.4% (9 of 55 live births) among untreated mothers. Conclusions. PCR is a useful tool for the detection of congenital CD, and the treatment of infected women of childbearing age seems to be useful for preventing vertical transmission.
dc.embargo.terms01-ene-2999
dc.formatapplication/pdf
dc.format.extent8
dc.identifier.citationClinical Infectious Diseases, Volume 56, Issue 4, 15 February 2013, Pages 496–50
dc.identifier.doihttps://doi.org/10.1093/cid/cis910
dc.identifier.urihttps://hdl.handle.net/10201/158669
dc.languageeng
dc.publisherOxford University Press
dc.relationThis study was supported by the Network of Tropical Diseases Research RICET (grants RD06/0021/1007 and RD06/0021/ 0014) and the Project of Research in Health (grant PS09/ 01956). M. C. T. and M. C. L. were also supported by the Junta de Andalucía (grant P08-CVI-04037), I + D + I National Plan (MEC-Spain), and FEDER (grant BFU2010-1670).
dc.relation.publisherversionhttps://academic.oup.com/cid/article-abstract/56/4/496/350761?redirectedFrom=PDF
dc.rights.accessRightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectCongenital
dc.subjectChagas
dc.subjectTrypanosoma cruzi
dc.subjectTreatment
dc.subjectPrevention
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleRisk factors and primary prevention of congenital Chagas disease in a nonendemic country
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublicationes
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