Publication: Morphometric evaluation of capillary basement membrane thickness in the quadriceps muscle of diabetic and nondiabetic Chinese hamsters.
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Date
1986
Authors
Sawada, Gerianne ; Wyse, Beatrice M. ; Blanksl, Margaret C. ; Vidmaiz, Thornas J. ; Guerritsen, George C. ; Dianil, Arthur R.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Quadriceps muscle capillaries from
19-23 month old genetically diabetic (XA and AC)
and nondiabetic (M) subline Chinese.. hamsters
were morphometrically evaluated to determine if
capillary basement membrane thickening (CBMT) is
a quantifiable complication of diabetes. Significant
CBMT was present in the diabetic XA Chinese hamsters
(49.37 nm tr 17.81, p .c 0.007) in comparison with the
nondiabetic M. hamsters (34.08 nm + 9.98). Although
there was a trend towards expansion of the muscle
capillary basement membranes in the diabetic AC
Chinese hamsters, the value was not statistically
significant. A nested analysis of variance showed
that the greatest source of variation in basement
membrane thickness occurred among capillaries within
each animal. In addition, a positive correlation
(r = 0.62; p< 0.002) existed between blood glucose
levels and CBMT in the XA subline. These data should
serve as guidelines for evaluation of antimicrovasc,ular
disease compounds which will be tested to determine
if they prevent or retard microangiopathy in the diabetic
Chinese hamster.
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