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Morphometric evaluation of capillary basement membrane thickness in the quadriceps muscle of diabetic and nondiabetic Chinese hamsters.

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dc.contributor.authorSawada, Geriannees
dc.contributor.authorWyse, Beatrice M.es
dc.contributor.authorBlanksl, Margaret C.
dc.contributor.authorVidmaiz, Thornas J.
dc.contributor.authorGuerritsen, George C.
dc.contributor.authorDianil, Arthur R.
dc.date.accessioned2011-01-17T12:38:52Z
dc.date.available2011-01-17T12:38:52Z
dc.date.issued1986
dc.description.abstractQuadriceps muscle capillaries from 19-23 month old genetically diabetic (XA and AC) and nondiabetic (M) subline Chinese.. hamsters were morphometrically evaluated to determine if capillary basement membrane thickening (CBMT) is a quantifiable complication of diabetes. Significant CBMT was present in the diabetic XA Chinese hamsters (49.37 nm tr 17.81, p .c 0.007) in comparison with the nondiabetic M. hamsters (34.08 nm + 9.98). Although there was a trend towards expansion of the muscle capillary basement membranes in the diabetic AC Chinese hamsters, the value was not statistically significant. A nested analysis of variance showed that the greatest source of variation in basement membrane thickness occurred among capillaries within each animal. In addition, a positive correlation (r = 0.62; p< 0.002) existed between blood glucose levels and CBMT in the XA subline. These data should serve as guidelines for evaluation of antimicrovasc,ular disease compounds which will be tested to determine if they prevent or retard microangiopathy in the diabetic Chinese hamster.
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/17796
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectMusclees
dc.subjectDiabetices
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.1 - Patología del sistema circulatorio, de los vasos sanguíneos. Transtornos cardiovasculareses
dc.titleMorphometric evaluation of capillary basement membrane thickness in the quadriceps muscle of diabetic and nondiabetic Chinese hamsters.es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol. 1, nº 1 (1986)