Publication: HLA-A*11:01 and HLA-C*04:01 are associated with severe COVID-19
Authors
Castro-Santos, Patricia ; Rojas-Martinez, Augusto ; Riancho, José A. ; Lapunzina, Pablo ; Flores, Carlos ; Carracedo, Angel ; Díaz-Peña, Roberto ; García-Vázquez, Elisa ; Scourge Cohort Group
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Publisher
John Wiley & Sons
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DOI
https://doi.org/10.1111/tan.15160
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info:eu-repo/semantics/article
Description
© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. This document is the Published, version of a Published Work that appeared in final form in HLA: Immune Response Genetics. To access the final edited and published work see https://doi.org/10.1111/tan.15160
Abstract
We analyzed the association between HLA polymorphisms and susceptibility to SARS-CoV-2 infection and disease severity. Genotyping data from a total of 9373 COVID-19-positive cases from the Spanish Coalition to Unlock Research on Host Genetics on COVID-19 (SCOURGE) consortium and 5943 population controls were included in the study. We found an association of the alleles HLA-B*14:02 and HLA-C*08:02 with a lower risk to COVID-19 infection (p = 0.006, OR = 0.84, 95% CI = [0.75–0.95], p = 0.024, OR = 0.86, 95% CI = [0.78–0.95], respectively). We also found the alleles HLA-A*11:01 and HLA- C*04:01 associated with disease severity (p = 0.033, OR = 1.16, 95% CI = [1.04–1.31], p = 0.045, OR = 1.14, 95% CI = [1.05–1.25], respectively). These
results suggest that an effective presentation of viral peptides by HLA class I alleles involve a faster infection clearance, decreasing the susceptibility and severity of COVID-19.
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Citation
HLA: Immune Response Genetics. 2023 102(6): 731-739
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