Publication: Influence and role of regulatory B cells in organ transplantation: the state of the art, prospects, and emerging insights
Authors
Fernández-González, Marina ; Llorente, Santiago ; Galián, José Antonio ; Botella, Carmen ; González-López, Rosana ; Alegría, María José ; Hita, Alicia ; Moya-Quiles, María Rosa ; Martinez-Banaclocha, Helios ; Muro-Pérez, Manuel ; Muro, Javier ; Minguela, Alfredo ; Legaz Pérez, Isabel ; Muro, Manuel
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Facultad de Química
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Publisher
MDPI
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DOI
https://doi.org/10.3390/antib14040095
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info:eu-repo/semantics/article
Description
Abstract
B cells have attracted increasing interest in the field of organ transplantation due to their newly discovered immunoregulatory properties in alloimmune responses. Traditionally, B cells have been primarily associated with adaptive immunity to foreign substances and alloreactive immune response to allografts, differentiating into antibody-producing plasma cells or memory cells upon antigen recognition and T cell collaboration. However, the existence of B cells with regulatory functions (Bregs) in humans has been widely confirmed, highlighting the presence of this subset, which has immunosuppressive properties and which might contribute to allograft tolerance, within the B cell compartment in humans and mice. In this mini review, we summarize all the information available in the published reports about the role of regulatory B cells in solid organ transplantation.
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Citation
Antibodies 2025, 14, 95
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