Publication: Treatment and new progress of neonatal hypoxic-ischemic brain damage
Authors
Yang, Lijun ; Zhao, Hehua ; Cui, Hong
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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Description
Abstract
Neonatal hypoxic ischemia (HI) results in
different extents of brain damage, and immature brain
tissue is particularly sensitive to the stimulation of HI.
Hypoxic-ischemic brain damage (HIBD) is a common
and serious nervous system disease in neonates, for both
full-term infants and preterm infants, and is one of the
main causes of neonatal death. The surviving infants are
often associated with cerebral palsy, mental retardation,
and other sequelae, which severely affect quality of life.
For term infants, hypoxia and ischemia mainly affect
gray matter, whereas in preterm infants, the white matter.
However, up to now, inadequate standards and specific
measures that can be used to treat hypoxic-ischemic
brain injury are available. Recently, in addition to
supportive therapy and symptomatic treatment, research
on the treatment of hypoxic-ischemic brain injury has
focused on the following aspects: hypothermia therapy,
stem cell therapy, neuroprotective agents, ibuprofen, and
combination therapy. In this review, we will summarize
the treatment of HIBD and make suggestions for the
future treatment direction
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