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Treatment and new progress of neonatal hypoxic-ischemic brain damage

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dc.contributor.authorYang, Lijun
dc.contributor.authorZhao, Hehua
dc.contributor.authorCui, Hong
dc.date.accessioned2022-12-07T08:29:29Z
dc.date.available2022-12-07T08:29:29Z
dc.date.issued2020
dc.description.abstractNeonatal hypoxic ischemia (HI) results in different extents of brain damage, and immature brain tissue is particularly sensitive to the stimulation of HI. Hypoxic-ischemic brain damage (HIBD) is a common and serious nervous system disease in neonates, for both full-term infants and preterm infants, and is one of the main causes of neonatal death. The surviving infants are often associated with cerebral palsy, mental retardation, and other sequelae, which severely affect quality of life. For term infants, hypoxia and ischemia mainly affect gray matter, whereas in preterm infants, the white matter. However, up to now, inadequate standards and specific measures that can be used to treat hypoxic-ischemic brain injury are available. Recently, in addition to supportive therapy and symptomatic treatment, research on the treatment of hypoxic-ischemic brain injury has focused on the following aspects: hypothermia therapy, stem cell therapy, neuroprotective agents, ibuprofen, and combination therapy. In this review, we will summarize the treatment of HIBD and make suggestions for the future treatment directiones
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.doihttps://doi.org/10.14670/HH-18-214
dc.identifier.eisbnHistology and Histopathology Vol. 35, nº9 (2020)es
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/126204
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectNeonatees
dc.subjectHypoxic-ischemic brain damagees
dc.subjectTreatmentes
dc.subjectHypothermiaes
dc.subjectStem cell therapyes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleTreatment and new progress of neonatal hypoxic-ischemic brain damagees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.35, nº9 (2020)