Publication:
Antimicrobial Susceptibility of Isolated from Sheep with Fibrinous Pneumonia

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10.2478_acve-2023-0013.pdf(218.93 KB)
Date
2023-07-01
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Authors
Galecio, Juan Sebastián ; Badillo, Elena ; Escudero, Elisa ; Corrales, Juan Carlos ; Yuste Pérez, María Teresa ; Marín, Pedro
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Publisher
Sciendo
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Farmacología
DOI
http://dx.doi.org/10.2478/acve-2023-0013
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Description
© 2023 The authors This document is the published version of a published work that appeared in final form in Acta Veterinaria-Beogra. . This document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0 To access the final edited and published work see: http://dx.doi.org/10.2478/acve-2023-0013
Abstract
Ovine respiratory complex is a signifi cant cause of death in sheep fl ocks, where Pasteurella multocida is the most frequent microorganisms isolated from animals with pneumonia. There is an urgent need to refi ne the use of different antimicrobials to avoid the problem of antimicrobial resistance and optimize the control of this disease in ovine livestock. The fi rst step in approaching this problem is gaining an insight into the antimicrobial susceptibility of ovine pathogens. This study evaluated the in vitro activity of tildipirosin, gamithromycin, oxytetracycline, and danofl oxacin against Pasteurella multocida strains isolated from sheep with fi brinous pneumonia. The strains were incubated following Clinical and Laboratory Standards Institute (CLSI) standard conditions and also with a modifi ed method by 25% supplementation with sheep serum. Minimum inhibitory concentrations (MIC) were determined using the broth microdilution technique. The lowest MIC90 under standard conditions and by supplementation with sheep serum was obtained with tildipirosin. Sheep serum signifi cantly reduced tildipirosin, gamithromycin, and danofl oxacin MIC values for Pasteurella multocida strains. In brief, the potency of tildipirosine, gamithromycin, and danofl oxacin against Pasteurella multocida increases when sheep serum is added to the culture media.
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Antimicrobial susceptibility , Pneumonia , Sheep , Pasteurella multocida
Citation
Acta Veterinaria-Beograd 2023, 73 (2), 171-178
URI
http://hdl.handle.net/10201/150287
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