Publication: Glomerular pathology in surviving pigs experimentally infected with african swine fever virus
Authors
Martín Fernández, José Javier ; Igual, A. ; Rueda, A. ; Sánchez-Vizcaino, J.M. ; Alonso-Martí, C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Twelve miniature pigs were inoculated with
an attenuated African swine fever virus to study
glomerular involvement in surviving pigs.
In acute phase. kidneys were severely affected and
displayed a glomerular capillary thrombosis with fibrin
deposition in vascular lumen, detected by immunofluorescence.
Fibrin-positive deposits were progressively
cleared between one to three months after infection in
surviving pigs. The histological picture in kidneys of
surviving pigs, up to one post-infection year, showed a
focal and segmental glomerulonephritis with hyalinosis,
and IgM and C3 deposition was detected by immunofluorescence.
Its pathogeny as an evolutive stage of acute
glomerular injury is pointed out.
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Citation
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