Publication: Immunohistochemical analysis of thymidylate synthase expression in gastric carcinoma: correlation with clinicopathological parameters and survival
Authors
Rogoza Mateja, Wiesława ; Domagala, Pawel ; Kaczmarczyk, Mariusz ; Mieżyńska Kurtycz, Joanna ; Ławniczak, Małgorzata ; Sulżyc Bielicka, Violetta ; Bielicki, Dariusz ; Karpińska Kaczmarczyk, Katarzyna ; Domagala, Wenancjusz
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-11-784
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info:eu-repo/semantics/article
Description
Abstract
The correlation of thymidylate synthase (TS)
expression in gastric cancers with tumor histology and
prognostic or predictive information remains unclear.
Most studies have involved Asian populations, with few
conducted in European cohorts. Moreover, all published
studies analyze TS expression using semi-quantitative
methods. This retrospective study evaluated the
association of TS expression in tumor cells with gastric
carcinoma histological type, with selected clinicopathological parameters, and with the prognosis of
patients who underwent surgical treatment. TS
expression was detected using immunochemistry and
objectively assessed by computerized image analysis of
tumor cells in 100 gastric cancers. We found that high
TS expression was significantly more common in
intestinal than in diffuse type of gastric cancer according
to Lauren classification (P=0.0003); in type I carcinomas
compared to type IV according to Goseki classification
(P=0.002); and in gastric cancers in men than women
(P=0.04). Low TS expression was found more often in
carcinomas in the middle and lower third of the stomach
than in cancers in the upper third of the stomach
(P=0.009 and P=0.001, respectively). In the subgroup of
25 patients without lymph node metastases (stage I+II),
high TS expression was associated with better DFS
(83% for high TS expression versus 38,5% for low TS
expression, P=0.03). The results: (1) indicate significant
correlation between the Lauren and Goseki
histopathological classifications of gastric cancer and TS
expression in tumor cells, (2) suggest that high TS
expression may be a positive prognostic marker with
regard to DFS in patients with gastric cancer without
involvement of regional lymph nodes who underwent
radical surgical treatment and were not treated with
preoperative chemotherapy. Prognostic results need
confirmation in larger cohorts.
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Citation
Histology and Histopathology, Vol.32, nº2, (2017)
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