Publication: lnfluence of zinc on ethanol-induced
Authors
Seyoum, G. ; Persaud, T.V.N.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
For normal fetal growth and developmet, an
ample sumpply of nutrients and oxygen is essential. The
placenta is the conduit for nutrient transfer and thus any
factor that alters normal placental structure and function
may adversely affect the nutritional status of the fetus.
The effect of ethanol ingestion and zinc supplementation
on placental structure was investigated by the
simultaneous administration of ethanol and zinc to
pregnant Sprague-Dawley rats from gestational day 6
through 12. One group of animals was given an ethanol
liquid diet, a second group received the ethanol liquid
diet plus zinc, and another group was pair-fed a control
liquid diet. Placentas were recovered on day 20 of
gestation. The mean placental weight in the ethanol
group was significantly higher than that in either the
pair-fed control or the ethanol plus zinc group. The
ethanol-treated group revealed more stagnated blood in
the basal-decidual and in the basal-labyrinthine
junctions. Intervillous spaces in the labyrinthine zones
were markedly dilated and filled with more blood
corpuscles compared to the pair-fed control group. The
giant cells of the basa1 zone were also larger in size in
the ethanol-treated group. The frequency of occurrence
of stagnated blood in either the labyrinthine zone and in
the basal-labyrinthine junction was less in the ethanol
plus zinc group compared to the ethanol group.
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