Publication: Accelerated Simple Preparation of Curcumin-Loaded Silk Fibroin/Hyaluronic Acid Hydrogels for Biomedical Applications
Authors
Chaala, M. ; Seeba, F. Z. ; Fuster, M. G. ; Moulefera, I. ; Montalbán, M. G. ; Carissimi, G. ; Víllora, G.
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Facultad de Química
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Publisher
MDPI
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Description
© 2023 by the authors____ This document is the published version of a published work that appeared in final form in Polymers ____
This document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0 ____
To access the final edited and published work see:
https://doi.org/10.3390/polym15030504
Abstract
The development of new biomaterials from natural fibres in the field of biomedicine have
attracted great interest in recent years. One of the most studied fibres has been silk fibroin produced
by the Bombyx mori worm, due to its excellent mechanical properties and its biodegradability and
bioavailability. Among the different biomaterials that can be prepared from silk fibroin, hydrogels
have attracted considerable attention due to their potential use in different fields, such as scaffolding,
cell therapy and biomedical application. Hydrogels are essentially a three-dimensional network of
flexible polymer chains that absorb considerable amounts of water and can be loaded with drugs
and/or cells inside to be used in a wide variety of applications. Here we present a simple sonication
process for the preparation of curcumin-hyaluronic acid-silk fibroin hydrogels. Different grades of
hydrogels were prepared by controlling the relative amounts of their components. The hydrogels
were physically and morphologically characterised by Fourier transform infrared spectroscopy (FTIR),
X-ray diffraction (XRD), thermogravimetric analysis (TGA) and field emission scanning electron
microscopy (FESEM) and their biological activity was tested in terms of cell viability in a fibroblast
cell line.
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