Publication: Visual deficits after traumatic brain injury
Authors
Rasiah, Pratheepa Kumari ; Geier, Ben ; Jha, Kumar Abhiram ; Gangaraju, Rajashekhar
item.page.secondaryauthor
item.page.director
Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
publication.page.editor
publication.page.department
DOI
https://doi.org/10.14670/HH-18-315
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Traumatic brain injury (TBI) is frequently
described as any head injury ceasing the brain's normal
function. Anatomically, developmentally, and
physiologically, the eye is deemed as an extension of the
brain. Vision in TBI is underrepresented, and the number
of active clinical trials in this field are sparse.
Frequently, visual problems are overlooked at the time
of TBI, often resulting in progressive vision loss,
lengthening, and impairing rehabilitation. TBI can be
either penetrative or non-penetrative, associated with
degeneration of neurons, apoptotic cell death,
inflammation, microglial activation, hemorrhage
associated with vascular dysfunction; however, precise
animal modeling that mimics the extensive visual
deficits of TBI pathology remain elusive. Recent works
in both the diagnostics and therapeutics fields are
starting to make substantial progress in the right
direction. Discussion of current advancements in TBI
animal models and the recent pathophysiological
findings related to the neuro-glia-vascular unit (NVU)
will help elucidate novel targets for potential lines of
therapeutics. Only over the past decade have newer
pharmaceutical and stem cell-based treatments begun to
come to light. The potency for these new lines of TBI
specific curatives will be discussed along with the
review of current blast-induced TBI models, providing
potential directions for future research.
publication.page.subject
Citation
item.page.embargo
Ir a EstadÃsticas
Este Ãtem está sujeto a una licencia Creative Commons. CC BY 4.0