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Role of isocitrate dehydrogenase 1/2 (IDH 1/2) gene mutations in human tumors

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dc.contributor.authorLiu, Xiang
dc.contributor.authorLing, Zhi-Qiang
dc.date.accessioned2020-12-17T10:35:06Z
dc.date.available2020-12-17T10:35:06Z
dc.date.issued2015
dc.description.abstractIn recent years, frequent isocitrate dehydrogenase 1/2 (IDH1/IDH2) gene mutations were found in a variety of tumors, which specifically alter arginine residues of catalytic active site in IDH1/IDH2 and confer new enzymatic function of directly catalyzing alpha-ketoglutarate (α-KG) to R-2-hydroxyglutarate (2- HG). 2-HG could competitively inhibit α-KG–dependent enzymes and might therefore contribute to tumorigenesis. In addition, mutation status of IDH1/IDH2 is closely related to the progress and prognosis of certain tumors. Thus IDH1/IDH2 is considered to be a promising biomarker for early diagnosis and prognosis and targeted therapy. In this study, the current research on IDH1/IDH2 mutation, especially the mechanisms and clinical characteristics related to tumor, are reviewed.es
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.citationHistology and histopathology, Vol. 30, nº10, (2015)
dc.identifier.doi10.14670/HH-11-643
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/100050
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectIsocitrate dehydrogenase 1/2 (IDH1/IDH2)es
dc.subjectMutationses
dc.subjectMethylationes
dc.subjectMetabolismes
dc.subjectTumorigenesises
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleRole of isocitrate dehydrogenase 1/2 (IDH 1/2) gene mutations in human tumorses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.30,nº10 (2015)