Publication: Aminopeptidases in Cardiovascular and Renal Function. Role as Predictive Renal Injury Biomarkers
Authors
Vargas, Félix ; Wangesteen, Rosemary ; Rodríguez-Gómez, Isabel ; García-Estañ, Joaquín
item.page.secondaryauthor
item.page.director
Publisher
MDPI
publication.page.editor
publication.page.department
DOI
https://doi.org/10.3390/ijms21165615
item.page.type
info:eu-repo/semantics/article
Description
© 2023. The authors.
This document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/
This document is the published version of a published work that appeared in final form in
International Journal of Molecular Sciences
Abstract
Aminopeptidases (APs) are metalloenzymes that hydrolyze peptides and polypeptides by
scission of the N-terminus amino acid and that also participate in the intracellular final digestion of
proteins. APs play an important role in protein maturation, signal transduction, and cell-cycle control,
among other processes. These enzymes are especially relevant in the control of cardiovascular and
renal functions. APs participate in the regulation of the systemic and local renin–angiotensin system
and also modulate the activity of neuropeptides, kinins, immunomodulatory peptides, and cytokines,
even contributing to cholesterol uptake and angiogenesis. This review focuses on the role of four key
APs, aspartyl-, alanyl-, glutamyl-, and leucyl-cystinyl-aminopeptidases, in the control of blood pressure
(BP) and renal function and on their association with different cardiovascular and renal diseases. In this
context, the effects of AP inhibitors are analyzed as therapeutic tools for BP control and renal diseases.
Their role as urinary biomarkers of renal injury is also explored. The enzymatic activities of urinary APs,
which act as hydrolyzing peptides on the luminal surface of the renal tubule, have emerged as early
predictive renal injury biomarkers in both acute and chronic renal nephropathies, including those induced
by nephrotoxic agents, obesity, hypertension, or diabetes. Hence, the analysis of urinary AP appears to be
a promising diagnostic and prognostic approach to renal disease in both research and clinical settings.
publication.page.subject
Citation
International Journal of Molecular Sciences 2020, 21, 5615;
item.page.embargo
Collections
Ir a Estadísticas
Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by/4.0/