Publication: Biosynthesis of a novel polymeric chitosan-betaxanthin and characterization of the first sugar-derived betalains and their effects in the in vivo model Caenorhabditis elegans
Authors
Guerrero Rubio, María Alejandra ; Hernández García, Samanta ; García Carmona, Francisco ; Gandía Herrero, Fernando
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Publisher
Elsevier
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DOI
https://doi.org/10.1016/j.carbpol.2020.117141
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info:eu-repo/semantics/article
Description
© 2020 Elsevier Ltd. All rights reserved.This document is the Published version of a Published Work that appeared in final form in Carbohydrate Polymers. To access the final edited and published work see https://doi.org/10.1016/j.carbpol.2020.117141
Abstract
Betaxanthins are nitrogenous plant pigments belonging to the family of betalains and they are known for their health-promoting effects and fluorescent properties. A novel biotechnological approach in the synthesis of these compounds has allowed the synthesis of high amounts of known betalains and of novel, tailor-made betalains through the condensation of the structural unit - betalamic acid - with amine groups of different compounds. Here we describe the synthesis and characterization of chitosan-betaxanthin, the first fluorescent polymeric betaxanthin which forms nanoparticles and that might combine the fluorescent properties of betalains and the properties of chitosan, a sugar polymer widely used with medical purposes. In addition, glucosamine, the structural unit of chitosan, and its stereoisomer galactosamine were shown to condense in solution with betalamic acid. This produced novel molecules with spectral and in vivo antioxidant and anti-aging properties similar to those of biological betaxanthins, which are the first sugar-derived betaxanthins described.
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Citation
Carbohydrate Polymers 252 (2021) 117141
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