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Bioactive compounds of tomato: Cancer chemopreventive effects and influence on the transcriptome in hepatocytes

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dc.contributor.authorPeriago, María Jesús
dc.contributor.authorNavarro-González, Inmaculada
dc.contributor.authorGarcía-Alonso, Javier
dc.contributor.departmentTecnología de Alimentos, Nutrición y Bromatología
dc.date.accessioned2024-01-28T08:53:07Z
dc.date.available2024-01-28T08:53:07Z
dc.date.created2017-10-10
dc.date.issued2018-01-03
dc.description©2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Published, version of a Published Work that appeared in final form in Journal of Functional Foods. To access the final edited and published work see https://doi.org/10.1016/j.jff.2018.01.003es
dc.description.abstractThe mechanisms of the effects of tomato extracts (containing lycopene and phenolic compounds) and these pure bioactive compounds on the viability, apoptosis, cell cycle, and the scavenging of ROS of HepG2 cells were investigated. Simultaneously, a transcriptomic analysis in human hepatocytes from obese patients, after the intake of tomato juice, was carried out using Human Gene Expression Array (Affymetrix). The viability of HepG2 decreased after exposure to tomato extracts and pure compounds, but none showed apoptotic activity; however, lycopene was able to inhibit cell cycle progression in phase S. Tomato extracts and pure compounds were able to decrease the ROS generation, the phenolic compounds being more effective than lycopene. Transcriptomic analysis suggested a involvement in the regulation of the cell cycle and apoptosis pathways after the intake of tomato juice, through the lycopene accumulation. These results showed that tomato juice have potential as functional foods for maintenance of liver health.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.doihttps://doi.org/10.1016/j.jff.2018.01.003
dc.identifier.eisbnJournal of Functional Foodses
dc.identifier.issn1756-4646
dc.identifier.urihttp://hdl.handle.net/10201/137865
dc.languageenges
dc.publisherElsevieres
dc.relationProjecto: “Secretaría de Estado de I+D+i, Ministerio de Econonomía y Competitividad” MINECO/FEDER-EU BFU2012-38103.es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1756464618300021es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectHepG2 cellses
dc.subjectPhenolic compoundses
dc.subjectLycopenees
dc.subjectTomatoes
dc.subjectGene expressiones
dc.subjectApoptosises
dc.subjectCell cycle arrestes
dc.subject.otherCDU::6 - Ciencias aplicadases
dc.titleBioactive compounds of tomato: Cancer chemopreventive effects and influence on the transcriptome in hepatocyteses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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