Publication: Bioactive compounds of tomato: Cancer chemopreventive effects and influence on the transcriptome in hepatocytes
Authors
Periago, María Jesús ; Navarro-González, Inmaculada ; García-Alonso, Javier
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Publisher
Elsevier
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Description
©2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
This document is the Published, version of a Published Work that appeared in final form in Journal of Functional Foods. To access the final edited and published work see https://doi.org/10.1016/j.jff.2018.01.003
Abstract
The mechanisms of the effects of tomato extracts (containing lycopene and phenolic compounds) and these pure
bioactive compounds on the viability, apoptosis, cell cycle, and the scavenging of ROS of HepG2 cells were
investigated. Simultaneously, a transcriptomic analysis in human hepatocytes from obese patients, after the
intake of tomato juice, was carried out using Human Gene Expression Array (Affymetrix). The viability of HepG2
decreased after exposure to tomato extracts and pure compounds, but none showed apoptotic activity; however,
lycopene was able to inhibit cell cycle progression in phase S. Tomato extracts and pure compounds were able to
decrease the ROS generation, the phenolic compounds being more effective than lycopene. Transcriptomic
analysis suggested a involvement in the regulation of the cell cycle and apoptosis pathways after the intake of
tomato juice, through the lycopene accumulation. These results showed that tomato juice have potential as
functional foods for maintenance of liver health.
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