Publication: New insights on hormones and factors that modulate Sertoli cell metabolism
Authors
Rato, Luís ; Meneses, Maria João ; Silva, Branca M. ; Sousa, Mário ; Alves, Marco G. ; Oliveira, Pedro F.
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-11-717
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info:eu-repo/semantics/article
Description
Abstract
Sertoli cells (SCs) play a key role in
spermatogenesis by providing the physical support for
developing germ cells and ensuring them the appropriate
nutrients, energy sources, hormones, and growth factors.
The control of SCs metabolism has been in the spotlight
for reproductive biologists, since it may be crucial to
determine germ cells’ fate. Indeed, the maintenance of
spermatogenesis is highly dependent on the metabolic
cooperation established between SCs and germ cells,
though this event has been overlooked. It depends on the
orchestration of various metabolic pathways and an
intricate network of signals. Several factors and/or
hormones modulate the metabolic activity of SCs, which
are major targets for the hormonal signalling that
regulates spermatogenesis. Any alteration in the
regulation of these cells’ metabolic behaviour may
compromise the normal development of spermatogenesis
and consequently, male fertility. In this context, SC
metabolism arises as a key regulation point for
spermatogenesis. Herein, we present an up-to-date
overview on the impact of hormones and factors that
modulate SC metabolism, with special focus on
glycolytic metabolism, highlighting their relevance in
determining male reproductive potential.
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