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New insights on hormones and factors that modulate Sertoli cell metabolism

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dc.contributor.authorRato, Luís
dc.contributor.authorMeneses, Maria João
dc.contributor.authorSilva, Branca M.
dc.contributor.authorSousa, Mário
dc.contributor.authorAlves, Marco G.
dc.contributor.authorOliveira, Pedro F.
dc.date.accessioned2021-07-01T10:26:47Z
dc.date.available2021-07-01T10:26:47Z
dc.date.issued2016
dc.description.abstractSertoli cells (SCs) play a key role in spermatogenesis by providing the physical support for developing germ cells and ensuring them the appropriate nutrients, energy sources, hormones, and growth factors. The control of SCs metabolism has been in the spotlight for reproductive biologists, since it may be crucial to determine germ cells’ fate. Indeed, the maintenance of spermatogenesis is highly dependent on the metabolic cooperation established between SCs and germ cells, though this event has been overlooked. It depends on the orchestration of various metabolic pathways and an intricate network of signals. Several factors and/or hormones modulate the metabolic activity of SCs, which are major targets for the hormonal signalling that regulates spermatogenesis. Any alteration in the regulation of these cells’ metabolic behaviour may compromise the normal development of spermatogenesis and consequently, male fertility. In this context, SC metabolism arises as a key regulation point for spermatogenesis. Herein, we present an up-to-date overview on the impact of hormones and factors that modulate SC metabolism, with special focus on glycolytic metabolism, highlighting their relevance in determining male reproductive potential.es
dc.formatapplication/pdfes
dc.format.extent15es
dc.identifier.doiDOI: 10.14670/HH-11-717
dc.identifier.eisbnHistology and histopathology: Vol.31, nº5 (2016)es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/110305
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectSertoli celles
dc.subjectSpermatogenesises
dc.subjectCell metabolismes
dc.subjectMetabolic modulationes
dc.subjectHormoneses
dc.subjectMale reproductiones
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleNew insights on hormones and factors that modulate Sertoli cell metabolismes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.31, nº5 (2016)