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Evolution of the gasdermin family and pyroptosis

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dc.contributor.authorAngosto-Bazarra, Diego
dc.contributor.authorGuijarro, Adriana
dc.contributor.authorPelegrín, Pablo
dc.contributor.departmentBioquímica y Biología Molecular B e Inmunologíaes
dc.date.accessioned2025-09-03T11:41:29Z
dc.date.available2025-09-03T11:41:29Z
dc.date.issued2023-09-19
dc.description© 2023. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. This document is the Submitted version of a Published Work that appeared in final form in . To access the final edited and published work see https://doi.org/10.1016/j.dci.2023.105060
dc.description.abstractGasdermins have been identified as playing a prominent role in the innate immune response as the executors of a specific type of cell death called pyroptosis. Specific proteolytic cleavage of gasdermins generates an N-terminal that oligomerizes and forms pores in the cell membrane. Although pyroptosis has been widely described in mammals, the importance of gasdermins and gasdermin-like proteins in inducing cell death in other vertebrates, in invertebrates and in other taxa including fungi and bacteria is still being determined. Mammalian, fungal and bacterial gasdermins have in common the fact that they go through the same stages (such as proteolytic activation) when inducing membrane rupture, which suggests that pyroptosis is as an ancient mechanism. In this review, we summarize the evolution and function of the gasdermin and gasdermin-like proteins in animals, fungi and bacteria.es
dc.formatapplication/pdfes
dc.format.extent25es
dc.identifier.citationDevelopmental and Comparative Immunology, volumen 149, diciembre 2023, 105060
dc.identifier.doihttps.//doi.org/10.1016/j.dci.2023.105060
dc.identifier.issnPrint: 0145-305X
dc.identifier.issnElectronic: 1879-0089
dc.identifier.urihttp://hdl.handle.net/10201/158125
dc.languageenges
dc.publisherElsevieres
dc.relationMCIN/AEI/10.13039/50110011033 (subvención PID2020-116709RB-I00 y PRE2021-100356), Fundación Séneca (subvenciones 20859/PI/18, 21897/PI/22, 21081/PDC/19), Instituto de Salud Carlos III (ISCIII) (proyectos DTS21/00080 y AC22/0009), cofinanciados por la Unión Europea, y el proyecto Horizonte de la UE 2020 PlasticHeal (subvención 965196)es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0145305X23012132?via%3Dihubes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectInflammationes
dc.subjectGasdermines
dc.subjectPyroptosises
dc.subjectInvertebrates
dc.subjectFungi
dc.subjectBacteria
dc.titleEvolution of the gasdermin family and pyroptosises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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