Publication:
Evolution of the gasdermin family and pyroptosis

Thumbnail Image
Files
Evolution of the gasdermin family and pyroptosis_FINAL.pdf(2.22 MB)
Date
2023-09-19
relationships.isAuthorOfPublication
relationships.isSecondaryAuthorOf
relationships.isDirectorOf
Authors
Angosto-Bazarra, Diego ; Guijarro, Adriana ; Pelegrín, Pablo
item.page.secondaryauthor
item.page.director
Publisher
Elsevier
publication.page.editor
publication.page.department
Bioquímica y Biología Molecular B e Inmunología
Description
© 2023. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. This document is the Submitted version of a Published Work that appeared in final form in . To access the final edited and published work see https://doi.org/10.1016/j.dci.2023.105060
Abstract
Gasdermins have been identified as playing a prominent role in the innate immune response as the executors of a specific type of cell death called pyroptosis. Specific proteolytic cleavage of gasdermins generates an N-terminal that oligomerizes and forms pores in the cell membrane. Although pyroptosis has been widely described in mammals, the importance of gasdermins and gasdermin-like proteins in inducing cell death in other vertebrates, in invertebrates and in other taxa including fungi and bacteria is still being determined. Mammalian, fungal and bacterial gasdermins have in common the fact that they go through the same stages (such as proteolytic activation) when inducing membrane rupture, which suggests that pyroptosis is as an ancient mechanism. In this review, we summarize the evolution and function of the gasdermin and gasdermin-like proteins in animals, fungi and bacteria.
publication.page.subject
Inflammation , Gasdermin , Pyroptosis , Invertebrates , Fungi , Bacteria
Citation
Developmental and Comparative Immunology, volumen 149, diciembre 2023, 105060
URI
http://hdl.handle.net/10201/158125
item.page.embargo
Collections
Artículos
Ir a Estadísticas