Publication: Effects of water salinity on melatonin levels in plasma and peripheral tissues and on melatonin binding sites in European sea bass (Dicentrarchus labrax)
Authors
López Olmeda, José Fernando ; Oliveira, Catarina ; Kalamarz, Hanna ; Kulczykowska, Ewa ; Delgado, María Jesús ; Sánchez Vázquez, Francisco Javier
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Publisher
Elsevier
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Description
©<2009>. This manuscript version is made available under the CC-BY-NC-ND license http://creativecommons.org/licenses/ccby-nc-nd/4.0/
This document is the Acepted version of a Published Work that appeared in final form in [Comparative Biochemistry and Physiology]. To access the final edited and published work see [https://doi.org/10.1016/j.cbpa.2008.12.003]
Abstract
Sea bass is a euryhaline fish that lives in a wide range of salinities and migrates
seasonally from lagoons to the open sea. However, to date, the influence of water salinity on
sea bass melatonin levels has not been reported. Here, we evaluated the differences in plasma
and tissue melatonin contents and melatonin binding sites in sea bass under four different
salinities: seawater (36 ‰), isotonic water (15 ‰), brackish (4 ‰) and freshwater (0 ‰).
Melatonin content was evaluated in plasma, whole brain, gills, intestine and kidney, while
melatonin binding sites were analyzed in different brain regions and in the neural retina.
Plasma melatonin levels at mid-dark varied among salinities, with the lowest value occurring
at seawater salinity (102 pg/ml), and the highest at freshwater (151 pg/ml). In gills and
intestine, however, the highest melatonin values were found in the seawater group (209 and
627 pg/g tissue, respectively). Melatonin binding sites in the brain also varied with salinity, with the highest density being observed at the lower salinities in optic tectum, cerebellum and
hypothalamus (30.3, 13.0, and 8.0 fmol/mg protein, respectively). Melatonin binding sites in
the retina showed a similar pattern, with the highest values in the fish maintained in
freshwater. Taken together, these results revealed that salinity influences melatonin
production and modifies the density of binding sites, which would point to a role for this
hormone in timing seasonal events in sea bass, including those linked to fish migration
between waters of different salinities.
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