Publication: Evaluation of a Comprehensive Profile of Salivary Analytes for the Diagnosis of the Equine Gastric Ulcer Syndrome
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Date
2022-11-23
Authors
Muñoz-Prieto, Alberto ; Cerón, José J. ; Rubio, Camila P. ; Contreras-Aguilar, María Dolores ; Pardo-Marín, Luis ; Ayala de la Peña, Ignacio ; Martín-Cuervo, María ; Holm Henriksen, Ida-Marie ; Arense-Gonzalo, Julián J. ; Tecles, Fernando ; Hansen, Sanni
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Publisher
MDPI
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Description
© 2022. The authors. This document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/
This document is the published version of a published work that appeared in final form in Animals
To access the final work, see DOI: https://doi.org/10.3390/ani12233261
Abstract
In this report, the measurement of salivary biomarkers as an aid for diagnosis of equine
gastric ulcer syndrome (EGUS) was studied. A comprehensive panel of 23 salivary analytes was
measured in the saliva of horses affected by EGUS and compared to healthy animals and horses
with other diseases clinically similar to EGUS but with a negative diagnosis at gastroscopic examination.
A total of 147 horses were included in the study and divided into heathy population (n =
12), the EGUS group (n = 110), and the group of horses with other diseases (n = 25). From the 23
analytes studied, 17 showed increased values in EGUS horses when compared to healthy ones, and
uric acid, triglycerides, and calcium were significantly increased in horses with EGUS compared to
the group of other diseases. The receiver operating characteristic curve analyses showed a modest
but significant discriminatory power of those three analytes to identify EGUS from other diseases
with similar symptoms. The discriminatory power enhanced when the results of the three analytes
were combined. In conclusion, the results showed that selected salivary analytes could have potential
use as biomarkers in horses with EGUS.
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