Publication: CD28 and KIR2D receptors as sensors of the immune status in heart and liver transplantation
Authors
Blanco García, R. M. ; López Álvarez, María R. ; Garrido, I. P. ; Salgado Cecilia, G. ; Campillo, José Antonio ; Bolarín, José Miguel ; Muro, Manuel ; García Alonso, A.M. ; Martínez Sánchez, María V. ; Peña Moral, J.M. de la ; Pascual Figal, Domingo A. ; Álvarez López, María Rocio ; Miras, M. ; Minguela, Alfredo ; Legaz Pérez, Isabel
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Publisher
Elsevier
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DOI
https://doi.org/10.1016/j.humimm.2011.06.004
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info:eu-repo/semantics/article
Description
© 2011 American Society for Histocompatibility and Immunogenetics. This document is the Published versión of a published Work that appeared in final form in Human Immunology. To access the final edited and published work see https://doi.org/10.1016/j.humimm.2011.06.004
Abstract
Viral infections and cellular acute rejection (AR) condition immunosuppressive therapy and compromise the evolution of allografts. Immune monitoring can be useful for ascertaining rejection and for differentiating allo-reaction from activation induced by infections. This work analyzes the usefulness of monitoring the expression of CD28 and KIR2D receptors in peripheral blood T lymphocytes by flow cytometry, to ascertain the immune response in heart and liver transplant recipients. In both types of transplant, the up-regulation of CD28 in CD4+ lymphocytes in the periods of greatest AR frequency indicates an effective allo-response, whereas the post-transplantation emergence of circulating CD8+CD28− and CD8+CD28−KIR2D+ T cells correlates with better early clinical results. Cytomegalovirus (CMV) infection, but not hepatitis C virus (HCV) or other infections, abrogated both CD28 up-regulation and CD8+CD28−KIR2D+ T-cell expansion. Our results show that monitoring the expression of CD28 and KIR2D receptors on T lymphocytes might be considered as sensors of the immune status of heart and liver recipients.
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Citation
Human Immunology 72 (2011) 841-848
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