Publication: Nutritional Importance of Carotenoids and Their Effect on Liver Health: A Review
Authors
Periago Castón, Mª Jesús ; Elvira-Torales, Laura Inés ; García-Alonso, Javier
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Publisher
MDPI
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DOI
https://doi.org/10.3390/antiox8070229
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info:eu-repo/semantics/article
Description
©2019. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/
This document is the Published, version of a Published Work that appeared in final form in Antioxidants. To access the final edited and published work see https://doi.org/10.3390/antiox8070229
Abstract
The consumption of carotenoids has beneficial e ects on health, reducing the risk of certain
forms of cancer, cardiovascular diseases, and macular degeneration, among others. The mechanism
of action of carotenoids has not been clearly identified; however, it has been associated with the
antioxidant capacity of carotenoids, which acts against reactive oxygen species and inactivating
free radicals, although it has also been shown that carotenoids modulate gene expression. Dietary
carotenoids are absorbed and accumulated in the liver and other organs, where they exert their
beneficial e ects. In recent years, it has been described that the intake of carotenoids can significantly
reduce the risk of su ering from liver diseases, such as non-alcoholic fatty liver disease (NAFLD).
This disease is characterized by an imbalance in lipid metabolism producing the accumulation of fat
in the hepatocyte, leading to lipoperoxidation, followed by oxidative stress and inflammation. In the
first phases, the main treatment of NAFLD is to change the lifestyle, including dietary habits. In this
sense, carotenoids have been shown to have a hepatoprotective e ect due to their ability to reduce
oxidative stress and regulate the lipid metabolism of hepatocytes by modulating certain genes. The
objective of this review was to provide a description of the e ects of dietary carotenoids from fruits
and vegetables on liver health.
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Citation
Antioxidants
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