Browsing by Subject "Non-alcoholic fatty liver disease (NAFLD)"
Now showing 1 - 3 of 3
Results Per Page
Sort Options
- PublicationOpen AccessNutritional Importance of Carotenoids and Their Effect on Liver Health: A Review(MDPI, 2019-07-19) Periago Castón, Mª Jesús; Elvira-Torales, Laura Inés; García-Alonso, Javier; Tecnología de Alimentos, Nutrición y BromatologíaThe consumption of carotenoids has beneficial e ects on health, reducing the risk of certain forms of cancer, cardiovascular diseases, and macular degeneration, among others. The mechanism of action of carotenoids has not been clearly identified; however, it has been associated with the antioxidant capacity of carotenoids, which acts against reactive oxygen species and inactivating free radicals, although it has also been shown that carotenoids modulate gene expression. Dietary carotenoids are absorbed and accumulated in the liver and other organs, where they exert their beneficial e ects. In recent years, it has been described that the intake of carotenoids can significantly reduce the risk of su ering from liver diseases, such as non-alcoholic fatty liver disease (NAFLD). This disease is characterized by an imbalance in lipid metabolism producing the accumulation of fat in the hepatocyte, leading to lipoperoxidation, followed by oxidative stress and inflammation. In the first phases, the main treatment of NAFLD is to change the lifestyle, including dietary habits. In this sense, carotenoids have been shown to have a hepatoprotective e ect due to their ability to reduce oxidative stress and regulate the lipid metabolism of hepatocytes by modulating certain genes. The objective of this review was to provide a description of the e ects of dietary carotenoids from fruits and vegetables on liver health.
- PublicationOpen AccessTomato Juice Supplementation Influences the Gene Expression Related to Steatosis in Rats(MDPI, 2018-09-02) Periago Castón, María Jesús; Elvira Torales, Laura Inés; Navarro González, Inmaculada; González Barrio, Rocío; Martín-Pozuelo, Gala; Domenech, Guillermo; García Alonso, Javier; Seva Alcaraz, Juan; Tecnología de Alimentos, Nutrición y BromatologíaThe objective of this work was to identify the effect of tomato juice on the expression of genes and levels of metabolites related to steatosis in rats. Male Sprague Dawley rats (8 weeks-old) were grouped (6 rats/group) in four experimental groups: NA (normal diet and water), NL (normal diet and tomato juice), HA (high-fat diet and water), and HL (high-fat diet and tomato juice). After an intervention period of 5 weeks, rats were sacrificed and biochemical parameters, biomarkers of oxidative stress, liver metabolites, and gene expression were determined. Although the H diet provoked dislipemia related to steatosis, no changes in isoprostanes or liver malondialdehyde (MDA) were observed. Changes in the gene expression of the HA group were produced by the high consumption of fat, whereas the consumption of tomato juice had different effects, depending on the diet. In the NL group, the genes involved in -oxidation were upregulated, and in groups NL and HL upregulation of CD36 and downregulation of APOB and LPL were observed. In addition, in the HL group the accumulation of lycopene upregulated the genes FXR and HNF4A, which have been suggested as preventive factors in relation to steatosis. Regarding the metabolomics study, intake of tomato juice stimulated the biosynthesis of glutathione and amino acids of the transulfurization pathway, increasing the levels of metabolites related to the antioxidant response.
- PublicationOpen AccessTomato Juice Supplementation Influences the Gene Expression Related to Steatosis in Rats(MDPI, 2018-09-02) Elvira Torales, Laura Inés; Navarro González, Inmaculada; González Barrio, Rocío; Martín Pozuelo, Gala; Doménech, Guillermo; García Alonso, Javier; Periago Castón, María Jesús; Seva Alcaraz, Juan; Enfermería