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Arrangement of the photoreceptor mosaic in a diabetic rat model imaged with multiphoton microscopy

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dc.contributor.authorBueno García, Juan Manuel
dc.contributor.authorCruz-Castillo, Ricardo
dc.contributor.authorAvilés-Trigueros, Marcelino
dc.contributor.authorBautista-Elivar, Nazario
dc.contributor.departmentFísica
dc.date.accessioned2025-10-08T11:42:57Z
dc.date.available2025-10-08T11:42:57Z
dc.date.copyright© 2020, Optical Society of America under the terms of the OSA Open Access Publishing Agreement
dc.date.issued2020-08-07
dc.description.abstractDiabetic retinopathy (DR) is defined as a microvascular pathology. However, some data have suggested that the retinal photoreceptors (PRs) might be important in the pathogenesis of this ocular disease. In this study the organization of the PRs in control and diabetic-induced rats was compared using multiphoton microscopy. The PR mosaic was imaged at different locations in non-stained retinas. The density of PRs was directly quantified from cell counting. The spatially resolved density presents a double-slope pattern (from the central retina towards the periphery) in both healthy and pathological samples, although the values for the latter were significantly lower all across the retinas. Moreover, Voronoi analysis was performed to explore changes in PR topography. In control specimens a hexagonally packed structure was dominant. However, despite the non-controlled effects of the disease in retinal structures, this PR regularity was fairly maintained in diabetic retinas.
dc.formatapplication/pdf
dc.format.extent14
dc.identifier.citationBiomed. Opt. Express 11, 4901-4914 (2020)
dc.identifier.doihttps://doi.org/10.1364/BOE.399835
dc.identifier.eissn2296-858X
dc.identifier.urihttp://hdl.handle.net/10201/165209
dc.languageeng
dc.publisherFrontiers Media
dc.relationFundación Séneca (19897/GERM/15)
dc.relation.publisherversionhttps://opg.optica.org/boe/fulltext.cfm?uri=boe-11-9-4901
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleArrangement of the photoreceptor mosaic in a diabetic rat model imaged with multiphoton microscopy
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublicationes
relation.isAuthorOfPublication460f1110-b358-474a-9e08-f92fabe4be2b
relation.isAuthorOfPublication.latestForDiscovery460f1110-b358-474a-9e08-f92fabe4be2b
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