Publication: Arrangement of the photoreceptor mosaic in a diabetic rat model imaged with multiphoton microscopy
Authors
Bueno García, Juan Manuel ; Cruz-Castillo, Ricardo ; Avilés-Trigueros, Marcelino ; Bautista-Elivar, Nazario
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Publisher
Frontiers Media
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Description
Abstract
Diabetic retinopathy (DR) is defined as a microvascular pathology. However, some data have suggested that the retinal photoreceptors (PRs) might be important in the pathogenesis of this ocular disease. In this study the organization of the PRs in control and diabetic-induced rats was compared using multiphoton microscopy. The PR mosaic was imaged at different locations in non-stained retinas. The density of PRs was directly quantified from cell counting. The spatially resolved density presents a double-slope pattern (from the central retina towards the periphery) in both healthy and pathological samples, although the values for the latter were significantly lower all across the retinas. Moreover, Voronoi analysis was performed to explore
changes in PR topography. In control specimens a hexagonally packed structure was dominant.
However, despite the non-controlled effects of the disease in retinal structures, this PR regularity
was fairly maintained in diabetic retinas.
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Citation
Biomed. Opt. Express 11, 4901-4914 (2020)
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