Publication: Immunocytochemical localization of the calcium-binding proteins calbindin D28K, calretinin and parvalbumin in bat visual cortex
Authors
Kim, Hang-Gu ; Gu, Ya-Nan ; Lee, Kyoung-Pil ; Lee, Ji-Gun ; Kim, Chan-Wook ; Lee, Ji-Won ; Jeong, Tae-Hee ; Jeong, Young-Wun ; Jeon, Chang-Jin
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
10.14670/HH-11-680
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info:eu-repo/semantics/article
Description
Abstract
It is a common misconception that bats are
blind, and various studies have suggested that bats have
visual abilities. The purpose of this study was to
investigate the cytoarchitecture of calbindin D28K
(CB)-, calretinin (CR)-, and parvalbumin (PV)-immunoreactive (IR) neurons in the bat visual cortex using
immunocytochemistry. The highest density of CB- and
PV-IR neurons was located in layer IV of the visual
cortex. The majority of CB- and PV-IR neurons were
characterized by a stellate or round/oval shape. CR-IR
neurons were predominantly located in layers II/III, and
the cells were principally round/oval in shape. Two-color
immunofluorescence revealed that 65.96%, 24.24%, and
77.00% of the CB-, CR-, and PV-IR neurons,
respectively, contained gamma-aminobutyric acid
(GABA). We observed calcium-binding protein (CBP)-
IR neurons in specific layers of the bat visual cortex and
in specific cell types. Many of the CBP-IR neurons were
GABAergic interneurons. These data provide useful
clues to aid in understanding the functional aspects of
the bat visual system.
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