Publication: The effect of somatostatin analog octreotide on diethylstilbestrol-induced
prolactin secretion, cell proliferation and
vascular changes in the rat anterior pituitary gland
Authors
Pawlikowski, M. ; Kunert-Radek, J. ; Grochal, M. ; Zielinski, K. ; Kulig, Andrzej
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The effects of diethylstilbestrol (DES) and of
long-acting somatostatin analog, octreotide (SMS) on
the rat anterior pituitary microvasculature have been
studied by means of computer-assisted image analysis.
Additionally, the effects of DES and SMS on prolactin
secretion and anterior pituitary cell proliferation have
been studied, as well. The vascularization was visualized
using Selye's method modified by Poely et al. (1964).
The prolactin serum levels were estimated by radioimmunoassay.
The proliferation indices were assessed
using bromodeoxyuridine incorporation assay. As
expected, it was found that DES sharply increased serum
prolactin levels and enhanced cell proliferation in the
anterior pituitary gland. DES also induced changes in
parameters of vascularization. Simultaneous treatment of
rats with SMS inhibited the DES-induced elevation of
prolactin levels and pituitary cell proliferation. It also
suppressed some but not al1 DES-induced changes in the
anterior pituitary vascularization. These data suggest that
the angio-inhibitory activity of SMS might be involved
in its anti-tumor action on pituitary adenomas, but not as
a sole or principal mechanism.
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