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The effect of somatostatin analog octreotide on diethylstilbestrol-induced prolactin secretion, cell proliferation and vascular changes in the rat anterior pituitary gland

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dc.contributor.authorPawlikowski, M.es
dc.contributor.authorKunert-Radek, J.es
dc.contributor.authorGrochal, M.
dc.contributor.authorZielinski, K.
dc.contributor.authorKulig, Andrzej
dc.date.accessioned2011-02-22T10:42:44Z
dc.date.available2011-02-22T10:42:44Z
dc.date.issued1997
dc.description.abstractThe effects of diethylstilbestrol (DES) and of long-acting somatostatin analog, octreotide (SMS) on the rat anterior pituitary microvasculature have been studied by means of computer-assisted image analysis. Additionally, the effects of DES and SMS on prolactin secretion and anterior pituitary cell proliferation have been studied, as well. The vascularization was visualized using Selye's method modified by Poely et al. (1964). The prolactin serum levels were estimated by radioimmunoassay. The proliferation indices were assessed using bromodeoxyuridine incorporation assay. As expected, it was found that DES sharply increased serum prolactin levels and enhanced cell proliferation in the anterior pituitary gland. DES also induced changes in parameters of vascularization. Simultaneous treatment of rats with SMS inhibited the DES-induced elevation of prolactin levels and pituitary cell proliferation. It also suppressed some but not al1 DES-induced changes in the anterior pituitary vascularization. These data suggest that the angio-inhibitory activity of SMS might be involved in its anti-tumor action on pituitary adenomas, but not as a sole or principal mechanism.es
dc.formatapplication/pdfes
dc.format.extent4es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/19014
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectOctreotidees
dc.subjectProlactines
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleThe effect of somatostatin analog octreotide on diethylstilbestrol-induced prolactin secretion, cell proliferation and vascular changes in the rat anterior pituitary glandes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.12, nº 4 (1997)