Publication: Chronodisruption and ambulatory circadian monitoring in cancer patients: beyond the body clock
Authors
Almaida Pagan, Pedro F. ; Torrente, María ; Campos Martínez, Manuel ; Provencio, Mariano ; Madrid, Juan Antonio ; Franco, Fabio ; Rodríguez Morilla, Beatriz ; Cantos, Blanca ; Sousa, Pedro A. ; Martínez Madrid, María José ; Pimentao, Joao ; Rol de Lama, María de los Ángeles
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Publisher
Springer
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DOI
https://doi.org/10.1007/s11912-021-01158-z
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info:eu-repo/semantics/article
Description
© The Author(s) 2022. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/
This document is the Published Manuscript version of a Published Work that appeared in final form in Current Oncology Reports. To access the final edited and published work see https://doi.org/10.1007/s11912-021-01158-z
Abstract
Purpose of ReviewCircadian rhythms impose daily rhythms a remarkable variety of metabolic and physiological functions, such as cell proliferation, inflammation, and DNA damage response. Accumulating epidemiological and genetic evidence indicates that circadian rhythms’ disruption may be linked to cancer. The integration of circadian biology into cancer research may offer new options for increasing cancer treatment effectiveness and would encompass the prevention, diagnosis, and treatment of this disease.Recent FindingsIn recent years, there has been a significant development and use of multi-modal sensors to monitor physical activity, sleep, and circadian rhythms, allowing, for the very first time, scaling accurate sleep monitoring to epidemiological research linking sleep patterns to disease, and wellness applications providing new potential applications.SummaryThis review highlights the role of circadian clock in tumorigenesis, cancer hallmarks and introduces the state-of-the-art in sleep-monitoring technologies, discussing the eventual application of insights in clinical settings and cancer research.
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Citation
Current Oncology Reports, 2022, Vol. 24, pp.135–149
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Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by/4.0/