To finish things well: cysteine methylation ensures selective GTPase membrane
localization and signalling.

Cansado Vizoso, José

Publication:
To finish things well: cysteine methylation ensures selective GTPase membrane localization and signalling.

dc.contributor.author	Cansado Vizoso, José
dc.contributor.department	Genética y Microbiología
dc.date.accessioned	2021-03-16T14:06:13Z
dc.date.available	2021-03-16T14:06:13Z
dc.date.issued	2017-09-19
dc.description.abstract	Isoprenylcysteine-O-Carboxyl Methyltransferase (ICMT) catalyzes the final step in the prenylation process of different proteins including members of the Ras superfamily of GTPases. While cysteine methylation is essential in mammalian cells for growth, membrane association, and signaling by Ras and Rho GTPases, its role during signal transduction events in simple eukaryotes like yeasts appears irrelevant. By using a multidisciplinary approach our group has recently shown that, contrary to this initial assumption, in the fission yeast Schizosaccharomyces pombe ICMT activity encoded by the Mam4 gene is not only important to promote selective plasma membrane targeting of Ras and specific Rho GTPases, but also to allow precise downstream signalling to the Mitogen Activated Protein Kinase (MAPK) and Target of Rapamycin (TOR) pathways in response to diverse environmental cues. Thus, the dynamic regulation of in vivo methylation as a modulator of GTPase localization and function is an evolutionary conserved mechanism, making fission yeast an appealing model organism to study the regulation of this process.	es
dc.format	application/pdf	es
dc.format.extent	8	es
dc.identifier.citation	Current Genetics, 2018, 64(2), 341-344
dc.identifier.doi	10.1007/s00294-017-0756-x
dc.identifier.uri	http://hdl.handle.net/10201/105010
dc.language	eng	es
dc.publisher	Springer	es
dc.relation	Ámbito del proyecto: Nacional. Agencia/entidad financiadora: Ministerio de Economía y Competitividad. Convocatoria: -Programa estatal de fomento de la investigación científica y técnica de excelencia. Subprograma estatal de generación de conocimiento (convocatoria 2014). Nombre del proyecto: -Interacción entre la ruta de MAP quinasas de integridad celular y otras vías de señalización intracelular en la levadura con fisión Código: BFU2014-52828-P	es
dc.relation.publisherversion	https://link.springer.com/article/10.1007%2Fs00294-017-0756-x	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject.other	CDU::5 - Ciencias puras y naturales::57 - Biología::579 - Microbiología	es
dc.title	To finish things well: cysteine methylation ensures selective GTPase membrane localization and signalling.	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es