Publication: To finish things well: cysteine methylation ensures selective GTPase membrane
localization and signalling.
Authors
Cansado Vizoso, José
item.page.secondaryauthor
item.page.director
Publisher
Springer
publication.page.editor
publication.page.department
DOI
10.1007/s00294-017-0756-x
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Isoprenylcysteine-O-Carboxyl Methyltransferase (ICMT) catalyzes the final step in the
prenylation process of different proteins including members of the Ras superfamily of GTPases.
While cysteine methylation is essential in mammalian cells for growth, membrane association,
and signaling by Ras and Rho GTPases, its role during signal transduction events in simple
eukaryotes like yeasts appears irrelevant. By using a multidisciplinary approach our group has
recently shown that, contrary to this initial assumption, in the fission yeast
Schizosaccharomyces pombe ICMT activity encoded by the Mam4 gene is not only important to
promote selective plasma membrane targeting of Ras and specific Rho GTPases, but also to
allow precise downstream signalling to the Mitogen Activated Protein Kinase (MAPK) and
Target of Rapamycin (TOR) pathways in response to diverse environmental cues. Thus, the
dynamic regulation of in vivo methylation as a modulator of GTPase localization and function is
an evolutionary conserved mechanism, making fission yeast an appealing model organism to
study the regulation of this process.
publication.page.subject
Citation
Current Genetics, 2018, 64(2), 341-344
item.page.embargo
Collections
Ir a Estadísticas
Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/