Publication: Substance P-like immunoreactivity in rat and cat carotid bodies, Light and electron microscopic studies
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Date
1986
Authors
I-li Chen ; Yates, Robert D. ; Hansen, John T.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Substance P-immunoreactive (SP-I) structures
in the carotid bodies of rats and cats were examined with
the light and electron microscopes. In both species SP-I
varicose nerve fibers were located singly in the interstitial
connective tissue in close association with blood vessels.
They were small unmyelinated fibers enveloped in a
common Schwann cell sheath with other SP-negative fibers.
Some of SP-I fibers contained large dense-cored granules
and small clear vesicles in addition to microtubules and
mitochondria and probably represented nerve fiber
varicosities. The latter often were found incompletely
invested by Schwann cell sheaths. SP-fibers were found
occasionally in the envelopes of supporting cells at the
periphery of parenchymal cell groups. However, none of
the nerve terminals making synaptic contacts with glomus
cells exhibited SP-like immunoreactivity. In cat carotid
bodies some glomus cells showed moderate to intense SPlike
immunoreactivity.The intense SP-I glomus cells
displayed numerous dense-cored vesicles of 85 to 140 nm
in diameter and frequently showed synaptic contacts with
SP-negative nerve terminals. In rat carotid bodies we were
unable to detect consistent SP-immunoreactivity in glomus
cells. Our results do not favor the hypothesis that SP is a
neurotransmitter/modulator in the chemoreceptor afferents
synapsing on glomus cells in either the cat or rat carotid
body. However our results support the hypothesis that SP
in cat glomus cells may play a role in the modulation of
chemoreceptor activity.
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