Publication: Study on impact of silver nanoparticles synthesized using aqueous extract of Ganoderma applanatum on thyroid and lipid parameters of albino rat
Authors
Dandapat, Sukumar ; Srivastava, Rohit ; Prasad Sinha, Manoranjan
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Publisher
Universidad de Murcia. Servicio de publicaciones
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DOI
http://dx.doi.org/10.6018/analesbio.43.14
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info:eu-repo/semantics/article
Description
Abstract
Se estudió el impacto de SNP cargadas con extracto de Ganoderma applanatum sobre el perfil tiroideo y lipídico de rata. Las
SNP (diámetro medio 58,77 nm; potencial zeta - 3,8) mV se analizaron mediante DLS. La microespectroscopía de infrarrojo con
transformada de Fourier proporcionó un pico de transmisión amplio
y elevado a 3248,12 cm-1
, que indica la carga bioquímica del extracto de G. applanatum en la superficie de los SNP. No se observó mortalidad ni cambios de comportamiento en la prueba de
toxicidad aguda. El grupo-1 recibió 1 mL de agua destilada, el grupo-2 y el grupo-3 recibieron 200 mg kg-1 y 400 mg kg-1 de
nanopartículas respectivamente. Una dosis de 400 mg kg-1 de
SNPs mostró una mayor actividad hipertiroidea e hipolipidímica en
comparación con el control y la dosis de 200 mg kg-1
.
Impact of silver nanoparticles loaded with Ganoderma applanatum extract on thyroid and lipid profile of rat were studied. Synthesized SNPs (Average diameter 58.77 nm; -13.8 mV zeta potential) were analysed by dynamic light scattering analysis. Fourier transform infrared spectroscopy provided broad and high transmission peak at 3248.12 cm-1 which indicates the loaded biochemical of the G. applanatum extract on the surface of SNPs. No mortality and behavioural changes were observed in the Acute toxicity test. Group-1 received 1 mL distilled water, group-2 and group-3 received 200 mg kg-1 and 400 mg kg-1 nanoparticles respectively. A 400 mg kg-1 dose of SNPs showed increased hyper thyroid and hypolipidimic activity as compared to control and 200 mg kg-1 dose.
Impact of silver nanoparticles loaded with Ganoderma applanatum extract on thyroid and lipid profile of rat were studied. Synthesized SNPs (Average diameter 58.77 nm; -13.8 mV zeta potential) were analysed by dynamic light scattering analysis. Fourier transform infrared spectroscopy provided broad and high transmission peak at 3248.12 cm-1 which indicates the loaded biochemical of the G. applanatum extract on the surface of SNPs. No mortality and behavioural changes were observed in the Acute toxicity test. Group-1 received 1 mL distilled water, group-2 and group-3 received 200 mg kg-1 and 400 mg kg-1 nanoparticles respectively. A 400 mg kg-1 dose of SNPs showed increased hyper thyroid and hypolipidimic activity as compared to control and 200 mg kg-1 dose.
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Nanopartículas , Hormona , Lípido , Tiroides , Colesterol , Nanoparticles , Hormone , Lipid , Thyroid
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