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Complex polysaccharide-based nanocomposites for 2 oral insulin delivery

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dc.contributor.authorCollado-González, Mar
dc.contributor.authorFreitas, Alessandra R.
dc.contributor.authorSantos, Ana Claudia
dc.contributor.authorFerreira, Nuno F.
dc.contributor.authorFerreri, Maria Cristina
dc.contributor.authorSequeira, Joana A.D.
dc.contributor.authorDíaz Baños, F. Guillermo
dc.contributor.authorVíllora Cano, Gloria
dc.contributor.authorVeiga, Francisco
dc.contributor.authorRibeiro, Antonio
dc.contributor.authorCarissimi, Guzmán
dc.contributor.departmentQuímica Física
dc.date.accessioned2024-02-07T09:16:49Z
dc.date.available2024-02-07T09:16:49Z
dc.date.created2020
dc.date.issued2020-01-15
dc.description© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) This document is the published version of a published work that appeared in final form in marine drugs
dc.description.abstractPolyelectrolyte nanocomposites rarely reach a stable state and aggregation often occurs. Here, we report the synthesis of nanocomposites for the oral delivery of insulin composed of alginate, dextran sulfate, poly-(ethyleneglycol) 4000, Poloxamer 188®, chitosan, and BSA. Chitosan seems to be essential for the final size of the nanocomposites. When the chitosan concentration used in the synthesis is 10-4 gcm-3, nanocomposites, microcomposites and milimetric composites are obtained. Reducing the chitosan concentration to 10-5 or 10-7 gcm-3 yields nanocomposites of 400-600 nm or 800-900 nm hydrodynamic diameter, respectively, measured by DLS. According to our results, the molecular weight of chitosan has little influence on the size of the composites. The enhanced stability of the newest nanocomposites synthesized was assessed with LUMiSizer®. The rounded shapes of the nanocomposites were confirmed by scanning electron microscopy. Analysis by HPLC revealed that, after loaded with insulin, about 80% of the drug was released from our nanocomposites.es
dc.formatapplication/pdfes
dc.format.extent18es
dc.identifier.citationMarine Drugs 2020, 18, 55
dc.identifier.doihttps://doi.org/10.3390/md18010055
dc.identifier.issnElectronic: 0141-8130
dc.identifier.urihttp://hdl.handle.net/10201/138836
dc.languageenges
dc.publisherMDPI (Basel, Switzerland)es
dc.relationThis work has been partially supported from the European Commission (FEDER/ERDF) and the Spanish MINECO (Ref. CTQ2011-25613 and Ref. CTQ2014-57467-R), the programme of support to the research of the Seneca Foundation of Science and Technology of Murcia (Projects 19499/PI/14 and 18946/JLI/13) and by the Nils Coordinated Mobility under grant 012-ABEL-CM-2014A. Mar Collado-González acknowledges support from University of Murcia for stays abroad of young researchers and doctoral students in the action lines of Campus Mare Nostrum (R273/2016). Alessandra R. Freitas acknowledges support from the Brazilian National Council for Scientific and Technological Development (Bolsista CNPq-Brasil). Ana C. Santos acknowledges support from the Portuguese Foundation for Science and Technology (FCT; SFRH/BD/109261/2015).es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectChitosanes
dc.subjectAlginate polysaccharide nanocompositees
dc.subjectStabilityes
dc.subjectLUMiSizeres
dc.subject.otherCDU::5 - Ciencias puras y naturaleses
dc.titleComplex polysaccharide-based nanocomposites for 2 oral insulin deliveryes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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relation.isAuthorOfPublicationa86472a8-4e68-4cbf-bd26-dcd57893ef2e
relation.isAuthorOfPublication507d3805-d0f6-44e1-a52f-7c110d434782
relation.isAuthorOfPublication.latestForDiscoveryba32f760-d55c-40a7-9452-62dfd47cbeaf
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