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C-Reactive protein levels in community acquired pneumonia

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C-Reactive protein levels in community acquired pneumonia.pdf(78.68 KB)
Date
2002-10-24
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Authors
García-Vázquez, Elisa ; Martínez, J.A. ; Mensa, J. ; Sánchez, F. ; Marcos, M.A. ; Roux, A. de ; Torres, A.
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Publisher
European Respiratory Society (ERS)
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publication.page.department
Medicina
DOI
https://doi.org/10.1183/09031936.03.00080203
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info:eu-repo/semantics/article
Description
©2003. ERS Journals Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. This document is the Accepted, version of a Published Work that appeared in final form in European Respiratory Journal. To access the final edited and published work see https://doi.org/10.1183/09031936.03.00080203
Abstract
The diagnostic value of C-reactive protein (CRP) admission serum levels as an indicator of the aetiology of community acquired pneumonia (CAP) was evaluated. A cohort of 1,222 patients with CAP was assessed. CRP levels were analysed in 258 patients with a single aetiological diagnosis. The mean CRP values in patients with pyogenic, atypical, viral and Legionella pneumophila pneumonia were: 16 mg?dL-1 , 13 mg?dL-1 , 14 mg?dL -1 and 25 mg?dL-1 , respectively. CRP levels were not significantly different among patients outcome research team (PORT) groups (19 mg?dL -1 in groups I–II, 16 mg?dL-1 in group III and 16 mg?dL -1 in groups IV–V. A cut-off point of 25 mg?dL-1 had a sensibility, specificity, positive predictive value and negative predictive value of 0.6, 0.83, 0.3, and 0.94, respectively. After controlling for age and PORT score, the odds of having a CRP level w25 mg?dL-1 was 6.9 times higher in patients with L. pneumophila pneumonia than in those with non-L. pneumophila pneumonia. Patients with Legionella pneumophila pneumonia had higher C-reactive protein levels than those with pneumonia of any other aetiology, independently of severity of infection. Being a cheap and readily available test, C-reactive protein may be a useful adjunctive procedure in the diagnosis of community acquired pneumonia.
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Aetiology , C-reactive protein , Community-acquired pneumonia , Diagnosis , Legionella pneumophila
Citation
European Respiratory Journal. 2003 21(4): 702-705
URI
http://hdl.handle.net/10201/142846
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