Publication: Quinoxalines Potential to Target Pathologies
Authors
Martínez-Esparza, M. ; Tristán-Manzano, María ; Guirado, Antonio ; Gálvez, Jesús ; García-Peñarrubia, Pilar ; Ruiz-Alcaraz, Antonio José
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Publisher
Bentham Science Publishers
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DOI
https://doi.org/10.2174/0929867322666150812144104
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info:eu-repo/semantics/article
Description
© 2015 Bentham Science Publishers. This document is the Published version of a Published Work that appeared in final form in Current Medicinal Chemistry. To access the final edited and published work see https://doi.org/10.2174/0929867322666150812144104
Abstract
The study of quinoxalines has increased immeasurably during the last two decades, due firstly to their relatively simple chemical synthesis, which has generated a vast variety of compounds with diverse structural modifications, and secondly, to the wide therapeutic potential and biological activities exhibited by this family of compounds. Quinoxalines constitute a rising biomedical class of low-molecular weight heterocyclic compounds with potential functions as antitumour, anti-inflammatory, antibacterial, antiviral, antifungal, antiparasitic and antidiabetic agents, as well as being of interest for the potential treatment of glaucoma, insomnia, cardiovascular and neurological diseases, among others. However, a deeper knowledge of the molecular targets of quinoxalines that fulfil a key role in certain pathologies is required for the development of new and more specific drugs through a rational design strategy to avoid undesirable side effects. In the present review, we summarize the most important molecular targets of the quinoxaline derivatives discovered to date, thus providing a first reference index for researchers to identify the potential targets of their quinoxalines derived collections, which could facilitate the development of new quinoxaline- based therapies.
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Citation
Current Medicinal Chemistry 22(26), 2015:3075-3108
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