Browsing by Subject "Receptors"

Now showing 1 - 4 of 4
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    Collagen-platelet interaction, platelet non-integrin receptors
    (Murcia : F. Hernández, 1999) Chiang, T.M.
    Platelet-collagen interaction is a complex event that involves ligand-receptor interaction. There are many adhesive non-integrin receptors for platelets to interact with various types of collagens. These nonintegrin receptors also serve as signal transducers both from the outside of platelets to the inside and possibly vice versa. The present review covers basic aspects of non-integrin receptor function and various signal transduction pathways.
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    Fine structure of the recptors at the myotendinous junction of human extraocular muscles
    (Murcia : F. Hernández, 1988) Sodi, A.; Corsi, M.; Faussone-Pellegrini, M.S; Salvi, G.
    The myotendinous junction of the human extraocular muscles was studied by electron microscopy. Some peculiar receptorial structures have been found in the majority of the samples examined. These structures are very small and consist of 1) the terminal portion of one muscle fibre, 2) the tendon into which it inserts and y), within the tendon, a rich nerve arborization, whose branches are always very close to the rnuscle component. Only one discontinuous layer, made up of tlat cells. which lack a basa1 lamina and often show pinocytotic vesicles, encapsules every musculo-tendinous complex. The tendinous component consists of amorphous ground substance of different electron density. of collagen and elastic fibres and is divided in compartments by ramified cells, which make an inner capsular-like covering to the nerve fibres. Three types of afferent nerve endings can be identified. One type is usually more frequent than the others, possesses a large number of neurotubules and neurofilaments and few mitochondria and is always surrounded by a Schwann cell which forms finger-like processes penetrating into the axoplasm. The second type is only partially enveloped by the Schwann cell. The axoplasm is devoid of neurotubules and contains few neurofilarnents, several mitochondria and groups of small clear vesicles placed in the areas uncovered by the glial sheath. The third one is completely surrounded by the Schwann cell, but is devoid of neurotubules and neurofilaments and full of mitochondria. These rnorphological features correspond well with the probable role of these receptorial structures, which is to ensure very exact and precise ocular movements.
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    Mast cells and wound healing: Still an open question
    (Universidad de Murcia, Departamento de Biologia Celular e Histiologia, 2025) Fernández Guarino, Montserrat; Bacci, Stefano
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    Quinoxalines Potential to Target Pathologies
    (Bentham Science Publishers, 2015) Martínez-Esparza, M.; Tristán-Manzano, María; Guirado, Antonio; Gálvez, Jesús; García-Peñarrubia, Pilar; Ruiz-Alcaraz, Antonio José; Bioquímica y Biología Molecular B e Inmunología
    The study of quinoxalines has increased immeasurably during the last two decades, due firstly to their relatively simple chemical synthesis, which has generated a vast variety of compounds with diverse structural modifications, and secondly, to the wide therapeutic potential and biological activities exhibited by this family of compounds. Quinoxalines constitute a rising biomedical class of low-molecular weight heterocyclic compounds with potential functions as antitumour, anti-inflammatory, antibacterial, antiviral, antifungal, antiparasitic and antidiabetic agents, as well as being of interest for the potential treatment of glaucoma, insomnia, cardiovascular and neurological diseases, among others. However, a deeper knowledge of the molecular targets of quinoxalines that fulfil a key role in certain pathologies is required for the development of new and more specific drugs through a rational design strategy to avoid undesirable side effects. In the present review, we summarize the most important molecular targets of the quinoxaline derivatives discovered to date, thus providing a first reference index for researchers to identify the potential targets of their quinoxalines derived collections, which could facilitate the development of new quinoxaline- based therapies.